Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
1R01GM052348-01A1
Application #
2191336
Study Section
Biophysical Chemistry Study Section (BBCB)
Project Start
1996-05-01
Project End
2000-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Albert Einstein College of Medicine
Department
Physiology
Type
Schools of Medicine
DUNS #
009095365
City
Bronx
State
NY
Country
United States
Zip Code
10461
Takamoto, Keiji; Chance, Mark R; Brenowitz, Michael (2004) Semi-automated, single-band peak-fitting analysis of hydroxyl radical nucleic acid footprint autoradiograms for the quantitative analysis of transitions. Nucleic Acids Res 32:E119
Takamoto, Keiji; Das, Rhiju; He, Qin et al. (2004) Principles of RNA compaction: insights from the equilibrium folding pathway of the P4-P6 RNA domain in monovalent cations. J Mol Biol 343:1195-206
Uchida, Takeshi; Takamoto, Keiji; He, Qin et al. (2003) Multiple monovalent ion-dependent pathways for the folding of the L-21 Tetrahymena thermophila ribozyme. J Mol Biol 328:463-78
Su, Linhui Julie; Brenowitz, Michael; Pyle, Anna Marie (2003) An alternative route for the folding of large RNAs: apparent two-state folding by a group II intron ribozyme. J Mol Biol 334:639-52
Uchida, Takeshi; He, Qin; Ralston, Corie Y et al. (2002) Linkage of monovalent and divalent ion binding in the folding of the P4-P6 domain of the Tetrahymena ribozyme. Biochemistry 41:5799-806
Maleknia, S D; Ralston, C Y; Brenowitz, M D et al. (2001) Determination of macromolecular folding and structure by synchrotron x-ray radiolysis techniques. Anal Biochem 289:103-15
Sclavi, B; Sullivan, M; Chance, M R et al. (1998) RNA folding at millisecond intervals by synchrotron hydroxyl radical footprinting. Science 279:1940-3
Chance, M R; Sclavi, B; Woodson, S A et al. (1997) Examining the conformational dynamics of macromolecules with time-resolved synchrotron X-ray 'footprinting'. Structure 5:865-9
Sclavi, B; Woodson, S; Sullivan, M et al. (1997) Time-resolved synchrotron X-ray ""footprinting"", a new approach to the study of nucleic acid structure and function: application to protein-DNA interactions and RNA folding. J Mol Biol 266:144-59