Active Site Studies of the Cytotoxin Restrictocin

Kenealy, William R.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of General Medical Sciences (NIGMS)
• Type: Research Project (R01)
• Project #: 5R01GM052706-03
• Application #: 2023037
• Study Section: Biochemistry Study Section (BIO)
• Project Start: 1994-08-09
• Project End: 1997-07-31
• Budget Start: 1996-08-01
• Budget End: 1997-07-31
• Support Year: 3
• Fiscal Year: 1996

Institution

• Name: J. Whittier Biologics, Inc.
• City: Madison
• State: WI
• Country: United States
• Zip Code: 53711

Publications

Brandhorst, T; Dowd, P F; Kenealy, W R (2001) The effect of fungal ribosome inactivating proteins upon feeding choice in C. freemani, and indications of a mutualistic relationship with A. restrictus. Environmental mycology. Mycopathologia 152:155-8

Yang, X; Moffat, K (1996) Insights into specificity of cleavage and mechanism of cell entry from the crystal structure of the highly specific Aspergillus ribotoxin, restrictocin. Structure 4:837-52

Brandhorst, T; Dowd, P F; Kenealy, W R (1996) The ribosome-inactivating protein restrictocin deters insect feeding on Aspergillus restrictus. Microbiology 142 ( Pt 6):1551-6

Brandhorst, T; Kenealy, W R (1995) Effects of leader sequences upon the heterologous expression of restrictocin in Aspergillus nidulans and Aspergillus niger. Can J Microbiol 41:601-11