Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM052737-02
Application #
2191875
Study Section
Molecular, Cellular, and Developmental Neurobiology Review Committee (MCDN)
Project Start
1995-01-01
Project End
1997-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Vermont & St Agric College
Department
Psychiatry
Type
Schools of Medicine
DUNS #
066811191
City
Burlington
State
VT
Country
United States
Zip Code
05405
Spalding, Tracy A; Trotter, Carol; Skjaerbaek, Niels et al. (2002) Discovery of an ectopic activation site on the M(1) muscarinic receptor. Mol Pharmacol 61:1297-302
Burstein, E S; Spalding, T A; Brann, M R (1998) Structure/function relationships of a G-protein coupling pocket formed by the third intracellular loop of the m5 muscarinic receptor. Biochemistry 37:4052-8
Spalding, T A; Burstein, E S; Henderson, S C et al. (1998) Identification of a ligand-dependent switch within a muscarinic receptor. J Biol Chem 273:21563-8
Burstein, E S; Brauner-Osborne, H; Spalding, T A et al. (1997) Interactions of muscarinic receptors with the heterotrimeric G proteins Gq and G12: transduction of proliferative signals. J Neurochem 68:525-33
Burstein, E S; Spalding, T A; Brann, M R (1997) Pharmacology of muscarinic receptor subtypes constitutively activated by G proteins. Mol Pharmacol 51:312-9
Spalding, T A; Burstein, E S; Wells, J W et al. (1997) Constitutive activation of the m5 muscarinic receptor by a series of mutations at the extracellular end of transmembrane 6. Biochemistry 36:10109-16
Burstein, E S; Spalding, T A; Brann, M R (1996) Constitutive activation of chimeric m2/m5 muscarinic receptors and delineation of G-protein coupling selectivity domains. Biochem Pharmacol 51:539-44
Hill-Eubanks, D; Burstein, E S; Spalding, T A et al. (1996) Structure of a G-protein-coupling domain of a muscarinic receptor predicted by random saturation mutagenesis. J Biol Chem 271:3058-65
Spalding, T A; Burstein, E S; Brauner-Osborne, H et al. (1995) Pharmacology of a constitutively active muscarinic receptor generated by random mutagenesis. J Pharmacol Exp Ther 275:1274-9