Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM052956-02
Application #
2192170
Study Section
Molecular and Cellular Biophysics Study Section (BBCA)
Project Start
1995-08-01
Project End
1999-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Rochester
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627
Maki, Angele S; Kim, TaeWoo; Kool, Eric T (2004) Direct comparison of A- and T-strand minor groove interactions in DNA curvature at A tracts. Biochemistry 43:1102-10
Lai, Jacob S; Kool, Eric T (2004) Selective pairing of polyfluorinated DNA bases. J Am Chem Soc 126:3040-1
Gao, Jianmin; Liu, Haibo; Kool, Eric T (2004) Expanded-size bases in naturally sized DNA: evaluation of steric effects in Watson-Crick pairing. J Am Chem Soc 126:11826-31
Delaney, James C; Henderson, Paul T; Helquist, Sandra A et al. (2003) High-fidelity in vivo replication of DNA base shape mimics without Watson-Crick hydrogen bonds. Proc Natl Acad Sci U S A 100:4469-73
Rausch, Jason W; Qu, Jin; Yi-Brunozzi, Hye Young et al. (2003) Hydrolysis of RNA/DNA hybrids containing nonpolar pyrimidine isosteres defines regions essential for HIV type 1 polypurine tract selection. Proc Natl Acad Sci U S A 100:11279-84
Maki, Angele; Brownewell, Floyd E; Liu, Dongyu et al. (2003) DNA curvature at A tracts containing a non-polar thymine mimic. Nucleic Acids Res 31:1059-66
Washington, M Todd; Helquist, Sandra A; Kool, Eric T et al. (2003) Requirement of Watson-Crick hydrogen bonding for DNA synthesis by yeast DNA polymerase eta. Mol Cell Biol 23:5107-12
Francis, Anthony W; Helquist, Sandra A; Kool, Eric T et al. (2003) Probing the requirements for recognition and catalysis in Fpg and MutY with nonpolar adenine isosteres. J Am Chem Soc 125:16235-42
Lai, Jacob S; Qu, Jin; Kool, Eric T (2003) Fluorinated DNA bases as probes of electrostatic effects in DNA base stacking. Angew Chem Int Ed Engl 42:5973-7
Liu, Haibo; Gao, Jianmin; Lynch, Stephen R et al. (2003) A four-base paired genetic helix with expanded size. Science 302:868-71

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