Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
1R01GM053136-01A1
Application #
2192416
Study Section
Physical Biochemistry Study Section (PB)
Project Start
1996-03-13
Project End
2000-02-29
Budget Start
1996-03-13
Budget End
1997-02-28
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Wayne State University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48202

  Publications

Read, M A; Brownell, J E; Gladysheva, T B et al. (2000) Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha. Mol Cell Biol 20:2326-33
Podust, V N; Brownell, J E; Gladysheva, T B et al. (2000) A Nedd8 conjugation pathway is essential for proteolytic targeting of p27Kip1 by ubiquitination. Proc Natl Acad Sci U S A 97:4579-84
Cook, W J; Martin, P D; Edwards, B F et al. (1997) Crystal structure of a class I ubiquitin conjugating enzyme (Ubc7) from Saccharomyces cerevisiae at 2.9 angstroms resolution. Biochemistry 36:1621-7