Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM053201-02
Application #
2192511
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1995-07-01
Project End
1999-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Boston College
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
045896339
City
Chestnut Hill
State
MA
Country
United States
Zip Code
02467
Stewart, Kristen M; McLaughlin, Larry W (2004) Four-arm oligonucleotide Ni(II)-cyclam-centered complexes as precursors for the generation of supramolecular periodic assemblies. J Am Chem Soc 126:2050-7
Chen, Dongli; Meena, Meena; Sharma, Sunil K et al. (2004) Formation and stability of a Janus-Wedge type of DNA triplex. J Am Chem Soc 126:70-1
Sharma, Sunil K; McLaughlin, Larry W (2004) Triplex mediated delivery of a platinum complex to a specific DNA target site. J Inorg Biochem 98:1570-7
Sharma, Sunil K; McLaughlin, Larry W (2002) Cross-linking of a DNA conjugate tethering a cis-bifunctional platinated complex to a target DNA duplex. J Am Chem Soc 124:9658-9
Gianolio, D A; Segismundo, J M; McLaughlin, L W (2000) Tethered naphthalene diimide-based intercalators for DNA triplex stabilization. Nucleic Acids Res 28:2128-34
Chen, D L; McLaughlin, L W (2000) Use of pK(a) differences to enhance the formation of base triplets involving C-G and G-C base pairs. J Org Chem 65:7468-74
Gianolio, D A; McLaughlin, L W (1999) Synthesis and triplex forming properties of pyrimidine derivative containing extended functionality. Nucleosides Nucleotides 18:1751-69
Wiederholt, K; McLaughlin, L W (1999) A 2,2""-bipyridine ligand for incorporation into oligodeoxynucleotides: synthesis, stability and fluorescence properties of ruthenium-DNA complexes. Nucleic Acids Res 27:2487-93
St Clair, A; Xiang, G; McLaughlin, L W (1998) Synthesis and triplex forming properties of an acyclic N7-glycosylated guanine nucleoside. Nucleosides Nucleotides 17:925-37
Xiang, G; Bogacki, R; McLaughlin, L W (1996) Use of a pyrimidine nucleoside that functions as a bidentate hydrogen bond donor for the recognition of isolated or contiguous G-C base pairs by oligonucleotide-directed triplex formation. Nucleic Acids Res 24:1963-70