Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM053448-03
Application #
2750065
Study Section
Special Emphasis Panel (ZRG3-BNP (02))
Project Start
1996-08-01
Project End
2000-07-31
Budget Start
1998-08-01
Budget End
1999-07-31
Support Year
3
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Kentucky
Department
Chemistry
Type
Schools of Pharmacy
DUNS #
832127323
City
Lexington
State
KY
Country
United States
Zip Code
40506
Tseng, Ping-Hui; Lin, Ho-Pi; Hu, Hongzhen et al. (2004) The canonical transient receptor potential 6 channel as a putative phosphatidylinositol 3,4,5-trisphosphate-sensitive calcium entry system. Biochemistry 43:11701-8
Yang, Chih-Cheng; Lin, Ho-Pi; Chen, Chang-Shi et al. (2003) Bcl-xL mediates a survival mechanism independent of the phosphoinositide 3-kinase/Akt pathway in prostate cancer cells. J Biol Chem 278:25872-8
Johnson, Amy J; Hsu, Ao-Lin; Lin, Ho-Pi et al. (2002) The cyclo-oxygenase-2 inhibitor celecoxib perturbs intracellular calcium by inhibiting endoplasmic reticulum Ca2+-ATPases: a plausible link with its anti-tumour effect and cardiovascular risks. Biochem J 366:831-7
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Wang, D S; Chen, C S (2001) Synthesis and biological evaluation of L-alpha-phosphatidyl-D-3-deoxy-3-heteromethyl-myo-inositols as phosphoinositide 3-kinase inhibitors. Bioorg Med Chem 9:3165-72
Ching, T T; Hsu, A L; Johnson, A J et al. (2001) Phosphoinositide 3-kinase facilitates antigen-stimulated Ca(2+) influx in RBL-2H3 mast cells via a phosphatidylinositol 3,4,5-trisphosphate-sensitive Ca(2+) entry mechanism. J Biol Chem 276:14814-20
Ching, T T; Lin, H P; Yang, C C et al. (2001) Specific binding of the C-terminal Src homology 2 domain of the p85alpha subunit of phosphoinositide 3-kinase to phosphatidylinositol 3,4,5-trisphosphate. Localization and engineering of the phosphoinositide-binding motif. J Biol Chem 276:43932-8
Wang, D S; Hsu, A L; Chen, C S (2001) A phosphatidylinositol 3,4,5-trisphosphate analogue with low serum protein-binding affinity. Bioorg Med Chem 9:133-9
Hsu, A L; Ching, T T; Wang, D S et al. (2000) The cyclooxygenase-2 inhibitor celecoxib induces apoptosis by blocking Akt activation in human prostate cancer cells independently of Bcl-2. J Biol Chem 275:11397-403
Hsu, A L; Ching, T T; Sen, G et al. (2000) Novel function of phosphoinositide 3-kinase in T cell Ca2+ signaling. A phosphatidylinositol 3,4,5-trisphosphate-mediated Ca2+ entry mechanism. J Biol Chem 275:16242-50

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