This new application outlines a broad and comprehensive program in the areas of bio-organic chemistry. Investigations described focus on mechanisms for flavin promoted oxidations of amines and related substrates. One major issue here is whether these reactions, occurring in chemical model or enzyme catalyzed processes, proceed by SET (radical) or polar (adduct formation) mechanisms. The planned studies, which combine model flavin chemical and enzymological efforts, have as their major goal the elucidation of the chemical mechanism for amine oxidation catalyzed by a class of physiologically important flavoenzymes known as the monoamine oxidases (MAO-A & -B). The mechanistic information gained from chemical and biochemical efforts will be used to develop novel strategies for the design of MAO-inactivators, substances which are known to play a significant role in the treatment of depression and Parkinson's disease. In addition, the techniques employed for elucidating the MAO-catalytic mechanism will be used to gain information about the potentially related catalytic pathways for flavin containing amino acid, alcohol and fatty acid ester dehydrogenases.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM053822-03
Application #
2668525
Study Section
Special Emphasis Panel (ZRG3-BNP (01))
Project Start
1996-03-01
Project End
2000-02-29
Budget Start
1998-03-01
Budget End
2000-02-29
Support Year
3
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of New Mexico
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
829868723
City
Albuquerque
State
NM
Country
United States
Zip Code
87131