Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM053905-02
Application #
2193307
Study Section
Surgery and Bioengineering Study Section (SB)
Project Start
1995-05-17
Project End
1998-03-31
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Koo, Lily Y; Irvine, Darrell J; Mayes, Anne M et al. (2002) Co-regulation of cell adhesion by nanoscale RGD organization and mechanical stimulus. J Cell Sci 115:1423-33
Murase, Shin-ichi; Horwitz, Alan F (2002) Deleted in colorectal carcinoma and differentially expressed integrins mediate the directional migration of neural precursors in the rostral migratory stream. J Neurosci 22:3568-79
Asthagiri, A R; Lauffenburger, D A (2001) A computational study of feedback effects on signal dynamics in a mitogen-activated protein kinase (MAPK) pathway model. Biotechnol Prog 17:227-39
Knight, B; Laukaitis, C; Akhtar, N et al. (2000) Visualizing muscle cell migration in situ. Curr Biol 10:576-85
Maheshwari, G; Brown, G; Lauffenburger, D A et al. (2000) Cell adhesion and motility depend on nanoscale RGD clustering. J Cell Sci 113 ( Pt 10):1677-86
Asthagiri, A R; Lauffenburger, D A (2000) Bioengineering models of cell signaling. Annu Rev Biomed Eng 2:31-53
Asthagiri, A R; Reinhart, C A; Horwitz, A F et al. (2000) The role of transient ERK2 signals in fibronectin- and insulin-mediated DNA synthesis. J Cell Sci 113 Pt 24:4499-510
Asthagiri, A R; Nelson, C M; Horwitz, A F et al. (1999) Quantitative relationship among integrin-ligand binding, adhesion, and signaling via focal adhesion kinase and extracellular signal-regulated kinase 2. J Biol Chem 274:27119-27
Asthagiri, A R; Horwitz, A F; Lauffenburger, D A (1999) A rapid and sensitive quantitative kinase activity assay using a convenient 96-well format. Anal Biochem 269:342-7
Maheshwari, G; Lauffenburger, D A (1998) Deconstructing (and reconstructing) cell migration. Microsc Res Tech 43:358-68

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