Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM053987-02
Application #
6013584
Study Section
Project Start
1998-01-01
Project End
2000-12-31
Budget Start
1998-01-01
Budget End
1998-12-31
Support Year
2
Fiscal Year
1999
Total Cost
Indirect Cost
Stahelin, Robert V; Subramanian, Preeti; Vora, Mohsin et al. (2007) Ceramide-1-phosphate binds group IVA cytosolic phospholipase a2 via a novel site in the C2 domain. J Biol Chem 282:20467-74
Cho, Wonhwa; Stahelin, Robert V (2006) Membrane binding and subcellular targeting of C2 domains. Biochim Biophys Acta 1761:838-49
Stahelin, Robert V; Hwang, Jeong H; Kim, Jin-Hahn et al. (2005) The mechanism of membrane targeting of human sphingosine kinase 1. J Biol Chem 280:43030-8
Subramanian, Preeti; Stahelin, Robert V; Szulc, Zdzislaw et al. (2005) Ceramide 1-phosphate acts as a positive allosteric activator of group IVA cytosolic phospholipase A2 alpha and enhances the interaction of the enzyme with phosphatidylcholine. J Biol Chem 280:17601-7
Stahelin, Robert V; Wang, Jiyao; Blatner, Nichole R et al. (2005) The origin of C1A-C2 interdomain interactions in protein kinase Calpha. J Biol Chem 280:36452-63
Malkova, Sarka; Long, Fei; Stahelin, Robert V et al. (2005) X-ray reflectivity studies of cPLA2{alpha}-C2 domains adsorbed onto Langmuir monolayers of SOPC. Biophys J 89:1861-73
Cho, Wonhwa; Stahelin, Robert V (2005) Membrane-protein interactions in cell signaling and membrane trafficking. Annu Rev Biophys Biomol Struct 34:119-51
Stahelin, Robert V; Digman, Michelle A; Medkova, Martina et al. (2005) Diacylglycerol-induced membrane targeting and activation of protein kinase Cepsilon: mechanistic differences between protein kinases Cdelta and Cepsilon. J Biol Chem 280:19784-93
Stahelin, Robert V; Ananthanarayanan, Bharath; Blatner, Nichole R et al. (2004) Mechanism of membrane binding of the phospholipase D1 PX domain. J Biol Chem 279:54918-26
Blatner, Nichole R; Stahelin, Robert V; Diraviyam, Karthikeyan et al. (2004) The molecular basis of the differential subcellular localization of FYVE domains. J Biol Chem 279:53818-27

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