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Rising, Kathleen A; Crenshaw, Charisse M; Koo, Hyun Jo et al. (2015) Formation of a Novel Macrocyclic Alkaloid from the Unnatural Farnesyl Diphosphate Analogue Anilinogeranyl Diphosphate by 5-Epi-Aristolochene Synthase. ACS Chem Biol 10:1729-36
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Faraldos, Juan A; Wu, Shuiqin; Chappell, Joe et al. (2010) Doubly deuterium-labeled patchouli alcohol from cyclization of singly labeled [2-(2)H(1)]farnesyl diphosphate catalyzed by recombinant patchoulol synthase. J Am Chem Soc 132:2998-3008
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O'Maille, Paul E; Malone, Arthur; Dellas, Nikki et al. (2008) Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthases. Nat Chem Biol 4:617-23
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Takahashi, Shunji; Yeo, Yunsoo; Greenhagen, Bryan T et al. (2007) Metabolic engineering of sesquiterpene metabolism in yeast. Biotechnol Bioeng 97:170-81
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Takahashi, Shunji; Yeo, Yun-Soo; Zhao, Yuxin et al. (2007) Functional characterization of premnaspirodiene oxygenase, a cytochrome P450 catalyzing regio- and stereo-specific hydroxylations of diverse sesquiterpene substrates. J Biol Chem 282:31744-54
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Faraldos, Juan A; Zhao, Yuxin; O'Maille, Paul E et al. (2007) Interception of the enzymatic conversion of farnesyl diphosphate to 5-epi-aristolochene by using a fluoro substrate analogue: 1-fluorogermacrene A from (2E,6Z)-6-fluorofarnesyl diphosphate. Chembiochem 8:1826-33
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Greenhagen, Bryan T; O'Maille, Paul E; Noel, Joseph P et al. (2006) Identifying and manipulating structural determinates linking catalytic specificities in terpene synthases. Proc Natl Acad Sci U S A 103:9826-31
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O'Maille, Paul E; Chappell, Joe; Noel, Joseph P (2006) Biosynthetic potential of sesquiterpene synthases: alternative products of tobacco 5-epi-aristolochene synthase. Arch Biochem Biophys 448:73-82
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Takahashi, Shunji; Zhao, Yuxin; O'Maille, Paul E et al. (2005) Kinetic and molecular analysis of 5-epiaristolochene 1,3-dihydroxylase, a cytochrome P450 enzyme catalyzing successive hydroxylations of sesquiterpenes. J Biol Chem 280:3686-96
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O'Maille, Paul E; Tsai, Ming-Daw; Greenhagen, Bryan T et al. (2004) Gene library synthesis by structure-based combinatorial protein engineering. Methods Enzymol 388:75-91
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Showing the most recent 10 out of 14 publications
