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Gotz, Marion G; James, Karen Ellis; Hansell, Elizabeth et al. (2008) Aza-peptidyl Michael acceptors. A new class of potent and selective inhibitors of asparaginyl endopeptidases (legumains) from evolutionarily diverse pathogens. J Med Chem 51:2816-32
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Jakobsen, Rasmus Kragh; Ono, Shin; Powers, James C et al. (2005) Fluorescently labeled inhibitors detect localized serine protease activities in Drosophila melanogaster pole cells, embryos, and ovarian egg chambers. Histochem Cell Biol 123:51-60
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Rukamp, Brian J; Kam, Chih Min; Natarajan, Sudah et al. (2004) Subsite specificities of granzyme M: a study of inhibitors and newly synthesized thiobenzyl ester substrates. Arch Biochem Biophys 422:9-22
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Kam, Chih-Min; Gotz, Marion G; Koot, Gretchen et al. (2004) Design and evaluation of inhibitors for dipeptidyl peptidase I (Cathepsin C). Arch Biochem Biophys 427:123-34
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James, Karen Ellis; Asgian, Juliana L; Li, Zhao Zhao et al. (2004) Design, synthesis, and evaluation of aza-peptide epoxides as selective and potent inhibitors of caspases-1, -3, -6, and -8. J Med Chem 47:1553-74
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Zeeuwen, Patrick L J M; van Vlijmen-Willems, Ivonne M J J; Olthuis, Diana et al. (2004) Evidence that unrestricted legumain activity is involved in disturbed epidermal cornification in cystatin M/E deficient mice. Hum Mol Genet 13:1069-79
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Gotz, Marion G; Caffrey, Conor R; Hansell, Elizabeth et al. (2004) Peptidyl allyl sulfones: a new class of inhibitors for clan CA cysteine proteases. Bioorg Med Chem 12:5203-11
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James, Karen Ellis; Gotz, Marion G; Caffrey, Conor R et al. (2003) Aza-peptide epoxides: potent and selective inhibitors of Schistosoma mansoni and pig kidney legumains (asparaginyl endopeptidases). Biol Chem 384:1613-8
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Asgian, Juliana L; James, Karen Ellis; Li, Zhao Zhao et al. (2002) Aza-peptide epoxides: a new class of inhibitors selective for clan CD cysteine proteases. J Med Chem 45:4958-60
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