Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM054412-03
Application #
2842594
Study Section
Project Start
1998-09-01
Project End
1999-04-30
Budget Start
1998-05-01
Budget End
1999-04-30
Support Year
3
Fiscal Year
1998
Total Cost
Indirect Cost
Lewis, K (2001) In search of natural substrates and inhibitors of MDR pumps. J Mol Microbiol Biotechnol 3:247-54
Guz, N R; Stermitz, F R; Johnson, J B et al. (2001) Flavonolignan and flavone inhibitors of a Staphylococcus aureus multidrug resistance pump: structure-activity relationships. J Med Chem 44:261-8
Lewis, K (2001) Riddle of biofilm resistance. Antimicrob Agents Chemother 45:999-1007
Ganapathy, M E; Huang, W; Rajan, D P et al. (2000) beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter. J Biol Chem 275:1699-707
Stermitz, F R; Tawara-Matsuda, J; Lorenz, P et al. (2000) 5'-Methoxyhydnocarpin-D and pheophorbide A: Berberis species components that potentiate berberine growth inhibition of resistant Staphylococcus aureus. J Nat Prod 63:1146-9
Brooun, A; Liu, S; Lewis, K (2000) A dose-response study of antibiotic resistance in Pseudomonas aeruginosa biofilms. Antimicrob Agents Chemother 44:640-6
Ganapathy, V; Prasad, P D; Ganapathy, M E et al. (2000) Placental transporters relevant to drug distribution across the maternal-fetal interface. J Pharmacol Exp Ther 294:413-20
Lewis, K (2000) Programmed death in bacteria. Microbiol Mol Biol Rev 64:503-14
Brooun, A; Tomashek, J J; Lewis, K (1999) Purification and ligand binding of EmrR, a regulator of a multidrug transporter. J Bacteriol 181:5131-3
Lewis, K (1998) Pathogen resistance as the origin of kin altruism. J Theor Biol 193:359-63

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