Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM054477-02
Application #
2193836
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1995-09-30
Project End
1999-09-29
Budget Start
1996-09-30
Budget End
1997-09-29
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Colorado Denver
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045

  Publications

Guzelian, P; Quattrochi, L; Karch, N et al. (2006) Does dioxin exert toxic effects in humans at or near current background body levels?: An evidence-based conclusion. Hum Exp Toxicol 25:99-105
Anderson, Garret R; Hasan, Aliya; Yin, Hao et al. (2006) Regulation of the CYP1A1 gene by 2,3,7,8-tetrachlorodibenzo-p-dioxin but not by beta-naphthoflavone or 3-methylcholanthrene is altered in hepatitis C virus replicon-expressing cells. Mol Pharmacol 70:1062-70
Narvaez, Marta J; Anderson, Garret R; Pickwell, George V et al. (2005) Characterization of adjacent E-box and nuclear factor 1-like DNA binding sequence in the human CYP1A2 promoter. J Biochem Mol Toxicol 19:78-86
Black, Virginia H; Quattrochi, Linda C (2004) Molecular cloning of the guinea pig CYP1A2 gene 5'-flanking region: identification of functional aromatic hydrocarbon response element and characterization of CYP1A2 expression in GPC16 cells. Drug Metab Dispos 32:595-602
Williams, Susanne N; Pickwell, George V; Quattrochi, Linda C (2003) A combination of tea (Camellia senensis) catechins is required for optimal inhibition of induced CYP1A expression by green tea extract. J Agric Food Chem 51:6627-34
Pickwell, George V; Shih, Hsueh; Quattrochi, Linda C (2003) Interaction of upstream stimulatory factor proteins with an E-box located within the human CYP1A2 5'-flanking gene contributes to basal transcriptional gene activation. Biochem Pharmacol 65:1087-96
Valerio Jr, L G; Kepa, J K; Pickwell, G V et al. (2001) Induction of human NAD(P)H:quinone oxidoreductase (NQO1) gene expression by the flavonol quercetin. Toxicol Lett 119:49-57
Allen, S W; Mueller, L; Williams, S N et al. (2001) The use of a high-volume screening procedure to assess the effects of dietary flavonoids on human cyp1a1 expression. Drug Metab Dispos 29:1074-9
Aitchison, K J; Gonzalez, F J; Quattrochi, L C et al. (2000) Identification of novel polymorphisms in the 5' flanking region of CYP1A2, characterization of interethnic variability, and investigation of their functional significance. Pharmacogenetics 10:695-704
Shih, H; Pickwell, G V; Quattrochi, L C (2000) Differential effects of flavonoid compounds on tumor promoter-induced activation of the human CYP1A2 enhancer. Arch Biochem Biophys 373:287-94

Showing the most recent 10 out of 13 publications