Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
1R01GM054627-01
Application #
2193973
Study Section
Biochemistry Study Section (BIO)
Project Start
1996-08-03
Project End
2000-07-31
Budget Start
1996-08-03
Budget End
1997-07-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Yale University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Petrov, Vasiliy M; Nolan, James M; Bertrand, Claire et al. (2006) Plasticity of the gene functions for DNA replication in the T4-like phages. J Mol Biol 361:46-68
Wang, C X; Zakharova, E; Li, J et al. (2004) Pre-steady-state kinetics of RB69 DNA polymerase and its exo domain mutants: effect of pH and thiophosphoryl linkages on 3'-5' exonuclease activity. Biochemistry 43:3853-61
Zakharova, E; Wang, J; Konigsberg, W (2004) The activity of selected RB69 DNA polymerase mutants can be restored by manganese ions: the existence of alternative metal ion ligands used during the polymerization cycle. Biochemistry 43:6587-95
Borjac-Natour, Jamilah M; Petrov, Vasiliy M; Karam, Jim D (2004) Divergence of the mRNA targets for the Ssb proteins of bacteriophages T4 and RB69. Virol J 1:4
Petrov, V M; Karam, J D (2004) Diversity of structure and function of DNA polymerase (gp43) of T4-related bacteriophages. Biochemistry (Mosc) 69:1213-8
Petrov, Vasiliy M; Karam, Jim D (2002) RNA determinants of translational operator recognition by the DNA polymerases of bacteriophages T4 and RB69. Nucleic Acids Res 30:3341-8
Petrov, Vasiliy M; Ng, San-San; Karam, Jim D (2002) Protein determinants of RNA binding by DNA polymerase of the T4-related bacteriophage RB69. J Biol Chem 277:33041-8
Bebenek, A; Dressman, H K; Carver, G T et al. (2001) Interacting fidelity defects in the replicative DNA polymerase of bacteriophage RB69. J Biol Chem 276:10387-97
Lin, T C; Wang, C X; Joyce, C M et al. (2001) 3'-5' Exonucleolytic activity of DNA polymerases: structural features that allow kinetic discrimination between ribo- and deoxyribonucleotide residues. Biochemistry 40:8749-55
Pavlov, A R; Karam, J D (2000) Nucleotide-sequence-specific and non-specific interactions of T4 DNA polymerase with its own mRNA. Nucleic Acids Res 28:4657-64

Showing the most recent 10 out of 17 publications