Abstract

The long term goal of the proposed research is to elucidate the mechanisms by which proteins and RNA molecules are imported and exported into and out of the nucleus. Dr. Davis uses Saccharomyces cerevisiae as an experimental system. The proposed research is designed to test a plausible model for the detailed events underlying translocation across the nuclear pore complex.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM054768-02
Application #
2519072
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1996-09-01
Project End
2000-08-31
Budget Start
1997-09-01
Budget End
1998-08-31
Support Year
2
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
Brandeis University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
616845814
City
Waltham
State
MA
Country
United States
Zip Code
02454

  Publications

Lee, Cheng-Sheng; Haber, James E (2015) Mating-type Gene Switching in Saccharomyces cerevisiae. Microbiol Spectr 3:MDNA3-0013-2014
Tam, W F; Lee, L H; Davis, L et al. (2000) Cytoplasmic sequestration of rel proteins by IkappaBalpha requires CRM1-dependent nuclear export. Mol Cell Biol 20:2269-84
Booth, J W; Belanger, K D; Sannella, M I et al. (1999) The yeast nucleoporin Nup2p is involved in nuclear export of importin alpha/Srp1p. J Biol Chem 274:32360-7