Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
1R01GM054903-01
Application #
2194217
Study Section
Biochemistry Study Section (BIO)
Project Start
1996-09-01
Project End
2000-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Florida
Department
Pharmacology
Type
Schools of Medicine
DUNS #
073130411
City
Gainesville
State
FL
Country
United States
Zip Code
32611
Perry, J Jefferson P; Hearn, Amy S; Cabelli, Diane E et al. (2009) Contribution of human manganese superoxide dismutase tyrosine 34 to structure and catalysis. Biochemistry 48:3417-24
Abreu, Isabel A; Hearn, Amy; An, Haiqain et al. (2008) The kinetic mechanism of manganese-containing superoxide dismutase from Deinococcus radiodurans: a specialized enzyme for the elimination of high superoxide concentrations. Biochemistry 47:2350-6
Quint, Patrick S; Domsic, John F; Cabelli, Diane E et al. (2008) Role of a glutamate bridge spanning the dimeric interface of human manganese superoxide dismutase. Biochemistry 47:4621-8
Emmler, Th; Ayala, I; Silverman, D et al. (2008) Combined NMR and computational study for azide binding to human manganese superoxide dismutase. Solid State Nucl Magn Reson 34:6-13
Zheng, Jiayin; Domsic, John F; Cabelli, Diane et al. (2007) Structural and kinetic study of differences between human and Escherichia coli manganese superoxide dismutases. Biochemistry 46:14830-7
Quint, Patrick; Reutzel, Robbie; Mikulski, Rose et al. (2006) Crystal structure of nitrated human manganese superoxide dismutase: mechanism of inactivation. Free Radic Biol Med 40:453-8
Chockalingam, Karuppiah; Luba, James; Nick, Harry S et al. (2006) Engineering and characterization of human manganese superoxide dismutase mutants with high activity and low product inhibition. FEBS J 273:4853-61
Quint, Patrick; Ayala, Idelisa; Busby, Scott A et al. (2006) Structural mobility in human manganese superoxide dismutase. Biochemistry 45:8209-15
Ayala, Idelisa; Perry, J Jefferson P; Szczepanski, Jan et al. (2005) Hydrogen bonding in human manganese superoxide dismutase containing 3-fluorotyrosine. Biophys J 89:4171-9
Abreu, Isabel A; Rodriguez, Jose A; Cabelli, Diane E (2005) Theoretical studies of manganese and iron superoxide dismutases: superoxide binding and superoxide oxidation. J Phys Chem B 109:24502-9

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