EXCEED THE SPACE PROVIDED. The long-term goal of this proposal is to better define relationships between structure and activity in aqueous solution. Specifically, the work proposed here will consider the facets of molecular structure relevant to affinity and specifity in aqueous association phenomonena. We will consider these issues in the context of small molecule chelates for various metal ions, in the development of high affinity protein-carbohydarte intereactions, and in the development of novel heterobivalent ligands for the matrix metalloprotease stromelysin. Our studies to define structure-function relationships in aqueous solution will facilitate the design and preparation of small molelcule ligands with a priori defined properties. These ligands could serve a wide variety of therapeutic roles, as agonist/antagonist ligands for various receptors and as inhibitors of various enzymes. PERFORMANCE SiTE(S) _anization, ci_,state) Department of Chemistry, Duke University, Durham, North Carolina KEY PERSONNEL. See instructions. Use continuation pages as needed to provide the required information in the format shown below. Start with Principal Investigator. List all other key personnel in alphabetical order, last name first. Name Organization Role on Project Eric Toone Department of Chemistry, Duke PI University PHS 398 (Rev. 05/01) Page _2 Form Page 2 Disclosure Permission StatemenE Applicable to SBIR/STTR Only. See instructions. [] Yes [] No ========================================Section End===========================================
