Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM058913-04
Application #
6687792
Study Section
Nutrition Study Section (NTN)
Program Officer
Okita, Richard T
Project Start
1998-12-01
Project End
2006-11-30
Budget Start
2003-12-01
Budget End
2004-11-30
Support Year
4
Fiscal Year
2004
Total Cost
$321,425
Indirect Cost
Name
University of Utah
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
009095365
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Poerschke, Robyn L; Franklin, Michael R; Bild, Andrea H et al. (2012) Major differences among chemopreventive organoselenocompounds in the sustained elevation of cytoprotective genes. J Biochem Mol Toxicol 26:344-53
Poerschke, Robyn L; Franklin, Michael R; Moos, Philip J (2008) Modulation of redox status in human lung cell lines by organoselenocompounds: selenazolidines, selenomethionine, and methylseleninic acid. Toxicol In Vitro 22:1761-7
El-Sayed, Wael M; Aboul-Fadl, Tarek; Roberts, Jeanette C et al. (2007) Murine hepatoma (Hepa1c1c7) cells: a responsive in vitro system for chemoprotective enzyme induction by organoselenium compounds. Toxicol In Vitro 21:157-64
Franklin, Michael R; Moos, Philip J; El-Sayed, Wael M et al. (2007) Pre- and post-initiation chemoprevention activity of 2-alkyl/aryl selenazolidine-4(R)-carboxylic acids against tobacco-derived nitrosamine (NNK)-induced lung tumors in the A/J mouse. Chem Biol Interact 168:211-20
El-Sayed, Wael M; Hussin, Warda A; Franklin, Michael R (2007) The antimutagenicity of 2-substituted selenazolidine-4-(R)-carboxylic acids. Mutat Res 627:136-45
El-Sayed, Wael M; Franklin, Michael R (2006) Hepatic chemoprotective enzyme responses to 2-substituted selenazolidine-4(R)-carboxylic acids. J Biochem Mol Toxicol 20:292-301
Li, Liang; Xie, Yang; El-Sayed, Wael M et al. (2005) Chemopreventive activity of selenocysteine prodrugs against tobacco-derived nitrosamine (NNK) induced lung tumors in the A/J mouse. J Biochem Mol Toxicol 19:396-405
Li, Liang; Xie, Yang; El-Sayed, Wael M et al. (2004) Characteristics of selenazolidine prodrugs of selenocysteine: toxicity, selenium levels, and glutathione peroxidase induction in A/J mice. Life Sci 75:447-59
Short, Megan D; Xie, Yang; Li, Liang et al. (2003) Characteristics of selenazolidine prodrugs of selenocysteine: toxicity and glutathione peroxidase induction in V79 cells. J Med Chem 46:3308-13
Dominick, P K; Cassidy, P B; Roberts, J C (2001) A new and versatile method for determination of thiolamines of biological importance. J Chromatogr B Biomed Sci Appl 761:1-12