in instruction on page 6. Appendix (Five collated sets, No page numbering necessary for Appendix.) Number of publications and manuscripts accepted or submitted for publication (Not to exceed 10) 2 __ Appendix 1: Hou, YM. (2000) """"""""Unusual synthesis by the Escherichia coli CCA-adding enzyme"""""""", RNA 6, 1031-1043. Appendix 2: Seth, M, Thurlow, DL, Hou, YM. (2002) """"""""Poly(C) synthesis by class I and class II CCA-adding enzymes"""""""", Biochemistry 41, 4521-4532. Letters of support (two), one each from Dr. Christine Chow and Dr. Ming-Daw Tsai. PHS 398 (Rev. 5/95) (Form Page 4) Page 2 EE Number pages consecutivelyat the bottom throughout the application. Do not use suffixes such as 3a, 3b.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
3R01GM068561-03S1
Application #
7483859
Study Section
Physiological Chemistry Study Section (PC)
Program Officer
Rhoades, Marcus M
Project Start
2004-04-01
Project End
2008-12-31
Budget Start
2007-01-01
Budget End
2007-12-31
Support Year
3
Fiscal Year
2007
Total Cost
$7,934
Indirect Cost
Name
Thomas Jefferson University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
053284659
City
Philadelphia
State
PA
Country
United States
Zip Code
19107
Ardell, David H; Hou, Ya-Ming (2016) Initiator tRNA genes template the 3' CCA end at high frequencies in bacteria. BMC Genomics 17:1003
Mei, Yide; Stonestrom, Aaron; Hou, Ya-Ming et al. (2010) Apoptotic regulation and tRNA. Protein Cell 1:795-801
Hou, Ya-Ming (2010) CCA addition to tRNA: implications for tRNA quality control. IUBMB Life 62:251-60
Liu, Cuiping; Betteridge, Thu; Hou, Ya-Ming (2009) Fluorophore labeling to monitor tRNA dynamics. Methods Enzymol 469:69-93
Kim, Sangbumn; Liu, Cuiping; Halkidis, Konstantine et al. (2009) Distinct kinetic determinants for the stepwise CCA addition to tRNA. RNA 15:1827-36
Dupasquier, Marcel; Kim, Sangbumn; Halkidis, Konstantine et al. (2008) tRNA integrity is a prerequisite for rapid CCA addition: implication for quality control. J Mol Biol 379:579-88
Hou, Ya-Ming; Gu, Shan-Qing; Zhou, Haiping et al. (2005) Metal-ion-dependent catalysis and specificity of CCA-adding enzymes: a comparison of two classes. Biochemistry 44:12849-59