The? ?goal? ?of? ?this? ?project? ?is? ?to? ?enable? ?scientific? ?discovery? ?and? ?advances? ?in? ?biomedical? ?research? ?through the? ?development? ?of? ?cutting-edge? ?software? ?tools? ?that? ?provide? ?integrated? ?visualizations? ?and? ?analyses? ?of molecular? ?structures? ?and? ?related? ?biological? ?information.? ?? ?Our? ?tools? ?can? ?be? ?applied? ?to? ?diverse? ?types? ?of biomolecular? ?data,? ?including? ?atomic-resolution? ?coordinates,? ?3D? ?cryo-EM? ?density? ?maps,? ?and? ?protein and? ?nucleic? ?acid? ?sequences,? ?annotations,? ?and? ?networks.? ?We? ?focus? ?on? ?unmet? ?software? ?needs? ?for? ?basic and? ?applied? ?biomedical? ?research? ?using? ?highly? ?trained? ?and? ?talented? ?staff,? ?with? ?excellent? ?interdisciplinary knowledge? ?and? ?specialized,? ?state-of-the-art? ?expertise? ?in? ?software? ?engineering,? ?computer? ?graphics visualization,? ?and? ?data? ?analysis.? ?? ?Our? ?primary? ?efforts? ?are? ?in? ?the? ?interactive? ?visualization? ?and? ?analysis? ?of structures? ?of? ?molecules,? ?molecular? ?assemblies,? ?and? ?protein? ?sequence-structure? ?relationships.? ?? ?These areas? ?are? ?critical? ?for? ?addressing? ?important? ?and? ?highly? ?relevant? ?biomedical? ?problems? ?such? ?as identifying? ?the? ?molecular? ?bases? ?of? ?disease,? ?identifying? ?targets? ?for? ?drug? ?development,? ?designing? ?drugs, and? ?engineering? ?proteins? ?with? ?new? ?functions.? ?? ?Our? ?software? ?tools? ?enable? ?scientists? ?to? ?understand, analyze,? ?and? ?illustrate? ?to? ?others? ?the? ?important? ?principles? ?of? ?molecular? ?structure,? ?function,? ?and interactions.? ?These? ?tools? ?are? ?widely? ?recognized? ?as? ?works? ?of? ?the? ?highest? ?quality,? ?and? ?are? ?available? ?for free? ?on? ?our? ?website? ?in? ?binary? ?and? ?source-code? ?form.? ?? ?We? ?support? ?and? ?maintain? ?these? ?tools,? ?and provide? ?detailed? ?documentation? ?and? ?tutorials.? ?Our? ?technological? ?developments? ?are? ?disseminated widely? ?via? ?scientific? ?publications,? ?lectures,? ?software? ?distribution,? ?and? ?video? ?animations.
PROJECT? ?NARRATIVE The? ?interactive? ?scientific? ?visualization? ?software? ?tools? ?we? ?develop? ?directly? ?address? ?many? ?of? ?the? ?critical challenges? ?researchers? ?face? ?as? ?they? ?discover,? ?analyze,? ?and? ?chronicle? ?the? ?major? ?biological? ?processes? ?inherent in? ?life? ?and? ?human? ?disease.? ?? ?Our? ?software? ?enables? ?spatially? ?complex? ?experimental? ?data? ?that? ?often? ?varies? ?over time? ?to? ?be? ?visualized? ?and? ?analyzed? ?and,? ?thus,? ?directly? ?leads? ?to? ?the? ?intellectual? ?understanding? ?of? ?important principles? ?in? ?biomedicine.? ?? ?We? ?strive? ?to? ?promote? ?the? ?application? ?of? ?interactive? ?3D? ?visualization? ?and? ?analysis techniques? ?to? ?critically? ?important? ?cutting-edge? ?problems? ?in? ?structural? ?and? ?computational? ?biology,? ?and? ?to? ?provide insight? ?into? ?molecular? ?and? ?cellular? ?function? ?that? ?can? ?be? ?directly? ?applied? ?to? ?problems? ?relevant? ?to? ?both? ?translational biomedical? ?research? ?and? ?precision? ?medicine.
