Abstract

The prevention of acute and chronic fetal hypoxia and fetal growth disorders depends upon a better understanding of placental and fetal respiratory physiology and metabolism from early to late pregnancy. The long-term goal of this project is to identify and study the factors that regulate the exchange of respiratory gases and metabolic substrates between maternal blood, placenta and fetal blood.
The specific aims are: (1) to study placental and fetal oxygen, carbohydrate and amino acid metabolism in early fetal life; (2) to test the effect of both even and uneven occlusion of the umbilical circulation on placental O2 transfer and fetal oxygenation; (3) to study the chronic regulation of fetal oxygenation by comparing placental respiratory function in A and B hemoglobin homozygous ewes that carry either singletons or twins; (4) to study the role of fetal insulin on placental and fetal metabolism; and (5) to study rates and sites of fructose utilization in the ovine fetus. The studies will be performed in chronic sheep preparations. The maternal-placental-fetal metabolic exchange will be quantitated by using techniques of blood flow measurement, chemical analysis of maternal arterial, uterine venous, umbilical arterial, venous blood, and tracer methodology.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD001866-21
Application #
3310144
Study Section
Human Embryology and Development Subcommittee 2 (HED)
Project Start
1977-02-01
Project End
1989-01-31
Budget Start
1986-02-01
Budget End
1987-01-31
Support Year
21
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
University of Colorado Denver
Department
Type
Schools of Medicine
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045

  Publications

Ashrafi, Ghazaleh; Schlehe, Julia S; LaVoie, Matthew J et al. (2014) Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin. J Cell Biol 206:655-70
Jozwik, M; Teng, C; Timmerman, M et al. (1998) Uptake and transport by the ovine placenta of neutral nonmetabolizable amino acids with different transport system affinities. Placenta 19:531-8
Barbera, A; Wilkening, R B; Teng, C et al. (1997) Metabolic alterations in the fetal hepatic and umbilical circulations during glucocorticoid-induced parturition in sheep. Pediatr Res 41:242-8
Ross, J C; Fennessey, P V; Wilkening, R B et al. (1996) Placental transport and fetal utilization of leucine in a model of fetal growth retardation. Am J Physiol 270:E491-503
Barbera, A; Jones 3rd, O W; Zerbe, G O et al. (1995) Ultrasonographic assessment of fetal growth: comparison between human and ovine fetus. Am J Obstet Gynecol 173:1765-9
Barbera, A; Jones 3rd, O W; Zerbe, G O et al. (1995) Early ultrasonographic detection of fetal growth retardation in an ovine model of placental insufficiency. Am J Obstet Gynecol 173:1071-4
Carter, B S; Moores Jr, R R; Teng, C et al. (1995) Main routes of plasma lactate carbon disposal in the midgestation fetal lamb. Biol Neonate 67:295-300
Vaughn, P R; Lobo, C; Battaglia, F C et al. (1995) Glutamine-glutamate exchange between placenta and fetal liver. Am J Physiol 268:E705-11
Wilkening, R B; Boyle, D W; Teng, C et al. (1994) Amino acid uptake by the fetal ovine hindlimb under normal and euglycemic hyperinsulinemic states. Am J Physiol 266:E72-8
Guyton, T S; De Wilt, H; Fennessey, P V et al. (1993) Alanine umbilical uptake, disposal rate, and decarboxylation rate in the fetal lamb. Am J Physiol 265:E497-503

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