Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
3R01HD011840-06S1
Application #
3311686
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1983-12-01
Project End
1985-06-30
Budget Start
1983-12-01
Budget End
1985-06-30
Support Year
6
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Oh, S S; Robinson, C H (1993) Mechanism of human placental aromatase: a new active site model. J Steroid Biochem Mol Biol 44:389-97
Childers, W E; Silverton, J V; Kellis Jr, J T et al. (1991) Inhibition of human placental aromatase by novel homologated 19-oxiranyl and 19-thiiranyl steroids. J Med Chem 34:1344-9
Cole, P A; Robinson, C H (1990) Mechanism and inhibition of cytochrome P-450 aromatase. J Med Chem 33:2933-42
Cole, P A; Robinson, C H (1990) Conversion of 19-oxo[2 beta-2H]androgens into oestrogens by human placental aromatase. An unexpected stereochemical outcome. Biochem J 268:553-61
Cole, P A; Bean, J M; Robinson, C H (1990) Conversion of a 3-desoxysteroid to 3-desoxyestrogen by human placental aromatase. Proc Natl Acad Sci U S A 87:2999-3003
Furth, P S; Rosenberger, J; Marcotte, P A et al. (1990) Synthesis of 2,2-dimethyl-4-hydroxy-4-androstene-3,17-dione as an inhibitor of aromatase. J Enzyme Inhib 4:131-5
Furth, P S; Robinson, C H (1989) Tritium release from [19-3H]-19,19-difluoroandrost-4-ene-3,17-dione during inactivation of aromatase. Biochemistry 28:1254-9
Childers, W E; Shih, M J; Furth, P S et al. (1987) Stereoselective inhibition of human placental aromatase. Steroids 50:121-34
Kellis Jr, J T; Childers, W E; Robinson, C H et al. (1987) Inhibition of aromatase cytochrome P-450 by 10-oxirane and 10-thiirane substituted androgens. Implications for the structure of the active site. J Biol Chem 262:4421-6