Abstract

Preterm lambs will be delivered and various ventilatory maneuvers performed (varying oxygen, tidal volume, and PEEP) to determine which particular strategy causes the least amount of lung injury. Next, preterm lambs will receive exogenous surfactant with different concentrations and combinations of apoproteins to determine if the injury process can be modified. Then, lambs will be exposed to endotoxin in utero to examine the impact of """"""""inflammatory priming"""""""" on the development of lung injury. Finally, the ventilation and surfactant strategies that are found to cause the least injury will be tested to see if the arrest in lung development can be prevented.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD012714-24
Application #
6625196
Study Section
Human Embryology and Development Subcommittee 1 (HED)
Program Officer
Raju, Tonse N
Project Start
1979-04-01
Project End
2005-11-30
Budget Start
2002-12-01
Budget End
2003-11-30
Support Year
24
Fiscal Year
2003
Total Cost
$299,700
Indirect Cost

  Institution

Name
Cincinnati Children's Hospital Medical Center
Department
Type
DUNS #
071284913
City
Cincinnati
State
OH
Country
United States
Zip Code
45229

  Publications

Hillman, Noah H; Gisslen, Tate; Polglase, Graeme R et al. (2014) Ventilation-induced increases in EGFR ligand mRNA are not altered by intra-amniotic LPS or ureaplasma in preterm lambs. PLoS One 9:e96087
Hillman, Noah H; Moss, Timothy J; Nitsos, Ilias et al. (2012) Moderate tidal volumes and oxygen exposure during initiation of ventilation in preterm fetal sheep. Pediatr Res 72:593-9
Pillow, J Jane; Musk, Gabrielle C; McLean, Carryn M et al. (2011) Variable ventilation improves ventilation and lung compliance in preterm lambs. Intensive Care Med 37:1352-9
Hillman, Noah H; Polglase, Graeme R; Pillow, J Jane et al. (2011) Inflammation and lung maturation from stretch injury in preterm fetal sheep. Am J Physiol Lung Cell Mol Physiol 300:L232-41
Hillman, Noah H; Nitsos, Ilias; Berry, Clare et al. (2011) Positive end-expiratory pressure and surfactant decrease lung injury during initiation of ventilation in fetal sheep. Am J Physiol Lung Cell Mol Physiol 301:L712-20
Hillman, Noah H; Kallapur, Suhas G; Pillow, J Jane et al. (2010) Airway injury from initiating ventilation in preterm sheep. Pediatr Res 67:60-5
Hillman, Noah H; Kallapur, Suhas G; Pillow, J Jane et al. (2010) Inhibitors of inflammation and endogenous surfactant pool size as modulators of lung injury with initiation of ventilation in preterm sheep. Respir Res 11:151
Kunzmann, Steffen; Glogger, Kerstin; Been, Jasper V et al. (2010) Thymic changes after chorioamnionitis induced by intraamniotic lipopolysaccharide in fetal sheep. Am J Obstet Gynecol 202:476.e1-9
Ball, Molly K; Hillman, Noah H; Kallapur, Suhas G et al. (2010) Body temperature effects on lung injury in ventilated preterm lambs. Resuscitation 81:749-54
Kramer, Boris W; Kallapur, Suhas G; Moss, Timothy J M et al. (2010) Modulation of fetal inflammatory response on exposure to lipopolysaccharide by chorioamnion, lung, or gut in sheep. Am J Obstet Gynecol 202:77.e1-9

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