Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
3R01HD012717-08S1
Application #
3311979
Study Section
Human Embryology and Development Subcommittee 2 (HED)
Project Start
1979-04-01
Project End
1989-07-31
Budget Start
1987-08-01
Budget End
1988-07-31
Support Year
8
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of Washington
Department
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Juchau, M R; Harris, C; Stark, K L et al. (1991) Cytochrome P450-dependent bioactivation of prodysmorphogens in cultured conceptuses. Reprod Toxicol 5:259-63
Shepard, T H; Fantel, A G; Kapur, R P (1991) Fetal coronary thrombosis as a cause of single ventricular heart. Teratology 43:113-7
Fantel, A G; Person, R E; Burroughs-Gleim, C et al. (1991) Asymmetric development of mitochondrial activity in rat embryos as a determinant of the defect patterns induced by exposure to hypoxia, hyperoxia, and redox cyclers in vitro. Teratology 44:355-62
Fantel, A G; Person, R E; Burroughs-Gleim, C J et al. (1990) Direct embryotoxicity of cocaine in rats: effects on mitochondrial activity, cardiac function, and growth and development in vitro. Teratology 42:35-43
Mirkes, P E; Little, S A (1990) Binding of (chloroethyl 3H) cyclophosphamide to rat embryo proteins: two-dimensional gel analysis. Teratology 41:195-204
Harris, C; Stark, K L; Luchtel, D L et al. (1989) Abnormal neurulation induced by 7-hydroxy-2-acetylaminofluorene and acetaminophen: evidence for catechol metabolites as proximate dysmorphogens. Toxicol Appl Pharmacol 101:432-46
Fantel, A G; Juchau, M R; Tracy, J W et al. (1989) Studies of mechanisms of niridazole-elicited embryotoxicity: evidence against a major role for covalent binding. Teratology 39:63-74
Shepard, T H; Fantel, A G; Fitzsimmons, J (1989) Congenital defect rates among spontaneous abortuses: twenty years of monitoring. Teratology 39:325-31
Shepard, T H; FitzSimmons, J M; Fantel, A G et al. (1989) Placental weights of normal and aneuploid early human fetuses. Pediatr Pathol 9:425-31
Fantel, A G; Juchau, M R; Burroughs, C J et al. (1989) Studies of embryotoxic mechanisms of niridazole: evidence that oxygen depletion plays a role in dysmorphogenicity. Teratology 39:243-51

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