Abstract

It is proposed to examine the development, distribution, origin and function of different components of antibody and cellular reactivity in human colostrum and milk. The investigations will be undertaken in groups of lactating post partum women immunized subcutaneously or intranasally with RA27/3 or HPV-77 DE/5 live attenuated rubella vaccine and in lactating women with other naturally acquired respiratory viral infections. A variety of currently available virologic and immunologic techniques will be employed. Studies will be undertaken to determine the relative contribution of bronchus associated lymphoid tissue (BALT) to the development of immunocompetence in human breast milk. Other studies will be initiated to delineate the role of breat feeding in the development of immunologic reactivity to viruses in the breat feeding infant and young child, using immunization with rubella virus vaccine as an investigative model. It is also hoped to study other immunologic aspects of maternal neonatal interaction which may be influenced by breast feeding. These studies should have significant relevance to protective mechanisms against viral infection in the developing human neonate.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD015943-03
Application #
3313335
Study Section
Immunological Sciences Study Section (IMS)
Project Start
1983-01-01
Project End
1986-12-31
Budget Start
1985-01-01
Budget End
1985-12-31
Support Year
3
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Children's Hospital (Buffalo)
Department
Type
DUNS #
City
Buffalo
State
NY
Country
United States
Zip Code
14222

  Publications

Ogra, P L; Faden, H S; Abraham, R et al. (1991) Effect of prior immunity on the shedding of virulent revertant virus in feces after oral immunization with live attenuated poliovirus vaccines. J Infect Dis 164:191-4
Krogh, V; Duffy, L C; Wong, D et al. (1989) Postpartum immunization with rubella virus vaccine and antibody response in breast-feeding infants. J Lab Clin Med 113:695-9
Cloutier, M M; Wong, D; Ogra, P L (1989) Respiratory syncytial virus alters electrophysiologic properties in cotton rat airway epithelium. Pediatr Pulmonol 6:164-8
Freihorst, J; Merrick, J M; Ogra, P L (1989) Effect of oral immunization with Pseudomonas aeruginosa on the development of specific antibacterial immunity in the lungs. Infect Immun 57:235-8
Okamoto, Y; Freihorst, J; Ogra, P L (1989) Maternal determinants of neonatal immune response to ovalbumin: effect of breast feeding on development of anti-ovalbumin antibody in the neonate. Int Arch Allergy Appl Immunol 89:83-9
Dharakul, T; Riepenhoff-Talty, M; Albini, B et al. (1988) Distribution of rotavirus antigen in intestinal lymphoid tissues: potential role in development of the mucosal immune response to rotavirus. Clin Exp Immunol 74:14-9
Zhaori, G; Sun, M; Ogra, P L (1988) Characteristics of the immune response to poliovirus virion polypeptides after immunization with live or inactivated polio vaccines. J Infect Dis 158:160-5
Welliver, R C (1988) Detection, pathogenesis, and therapy of respiratory syncytial virus infections. Clin Microbiol Rev 1:27-39
Leibovitz, E; Freihorst, J; Piedra, P A et al. (1988) Modulation of systemic and mucosal immune responses to inhaled ragweed antigen in experimentally induced infection with respiratory syncytial virus implication in virally induced allergy. Int Arch Allergy Appl Immunol 86:112-6
Rosner, I K; Welliver, R C; Edelson, P J et al. (1987) Effect of ribavirin therapy on respiratory syncytial virus-specific IgE and IgA responses after infection. J Infect Dis 155:1043-7

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