The objectives of the project are to characterize the positional information in the integument of arthropods, and to study how positional information is translated into form.
The specific aim i s to test and extend the fluid elastic shell model for the shaping of epithelia during development. This model has important implications for the processes which shape epithelia in early stages of human development. Tests of the model will be performed on the hypodermis, the monolayered epithelium underlying the integument of insects and crustaceans. The mechanical properties of the hypodermis will be investigated by deforming vesicles of hypodermis prepared in vitro, and measuring the resulting changes of tissue and cell shape. Implications of the model for the large-scale form of body parts will be tested by grafting patches of integument to ectopic sites in vivo, and characterizing the deformations of tissue and cell shape which occur during the post-operative regulation of pattern and form.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
2R01HD016577-04
Application #
3313753
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1981-09-01
Project End
1988-02-29
Budget Start
1985-03-01
Budget End
1986-02-28
Support Year
4
Fiscal Year
1985
Total Cost
Indirect Cost
Name
University of Illinois Urbana-Champaign
Department
Type
Schools of Arts and Sciences
DUNS #
041544081
City
Champaign
State
IL
Country
United States
Zip Code
61820
Mittenthal, J E; Nuelle, J R (1988) Discontinuities of pattern and rules for regeneration in limbs of crayfish. Dev Biol 126:315-26
Clarke, B S; Mittenthal, J E; Arcuri, P A (1988) An extremal criterion for epimorphic regeneration. Bull Math Biol 50:595-634