Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD016580-15
Application #
2197323
Study Section
Reproductive Biology Study Section (REB)
Project Start
1981-09-01
Project End
1996-04-30
Budget Start
1996-01-01
Budget End
1996-04-30
Support Year
15
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Connecticut
Department
Anatomy/Cell Biology
Type
Schools of Dentistry
DUNS #
City
Farmington
State
CT
Country
United States
Zip Code
06030
Nishimura, Hitoshi; Gupta, Surabhi; Myles, Diana G et al. (2011) Characterization of mouse sperm TMEM190, a small transmembrane protein with the trefoil domain: evidence for co-localization with IZUMO1 and complex formation with other sperm proteins. Reproduction 141:437-51
He, Zhi-Yong; Gupta, Surabhi; Myles, Diana et al. (2009) Loss of surface EWI-2 on CD9 null oocytes. Mol Reprod Dev 76:629-36
Zhu, Guo-Zhang; Gupta, Surabhi; Myles, Diana Gold et al. (2009) Testase 1 (ADAM 24) a sperm surface metalloprotease is required for normal fertility in mice. Mol Reprod Dev 76:1106-14
Gupta, Surabhi; Primakoff, Paul; Myles, Diana G (2009) Can the presence of wild-type oocytes during insemination rescue the fusion defect of CD9 null oocytes? Mol Reprod Dev 76:602
Nishimura, Hitoshi; Myles, Diana G; Primakoff, Paul (2007) Identification of an ADAM2-ADAM3 complex on the surface of mouse testicular germ cells and cauda epididymal sperm. J Biol Chem 282:17900-7
Runge, Kathryn E; Evans, James E; He, Zhi-Yong et al. (2007) Oocyte CD9 is enriched on the microvillar membrane and required for normal microvillar shape and distribution. Dev Biol 304:317-25
Primakoff, Paul; Myles, Diana G (2007) Cell-cell membrane fusion during mammalian fertilization. FEBS Lett 581:2174-80
Stein, Kathryn K; Go, Jowell C; Lane, William S et al. (2006) Proteomic analysis of sperm regions that mediate sperm-egg interactions. Proteomics 6:3533-43
Ellerman, Diego A; Myles, Diana G; Primakoff, Paul (2006) A role for sperm surface protein disulfide isomerase activity in gamete fusion: evidence for the participation of ERp57. Dev Cell 10:831-7
Stein, Kathryn K; Go, Jowell C; Primakoff, Paul et al. (2005) Defects in secretory pathway trafficking during sperm development in Adam2 knockout mice. Biol Reprod 73:1032-8

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