Abstract

This application is to transfer the above grant to Cornell to enable us to conclude the original experiments proposed in our successful application. The chronically catheterized fetal sheep with indwelling vascular catheters will be used to study the evolution of myometrial activity following 1) fetal death, 2) initiation of premature parturition by the infusion of ACTH1-24 to the fetus. These are the only two protocols remaining from the original application. The significance of these studies is that they will throw light on normal and abnormal human labor patterns.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD017129-04
Application #
3314193
Study Section
Human Embryology and Development Subcommittee 2 (HED)
Project Start
1982-01-01
Project End
1986-06-30
Budget Start
1984-12-01
Budget End
1986-06-30
Support Year
4
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Cornell University
Department
Type
Schools of Veterinary Medicine
DUNS #
City
Ithaca
State
NY
Country
United States
Zip Code
14850

  Publications

Figueroa, J P; Massmann, A; Pimentel, G et al. (1987) Characteristics of the electromyogram recorded from the mesometrium of the pregnant ewe from 106 days' gestation to delivery: similarities with and differences from the electromyogram obtained from the myometrium. Am J Obstet Gynecol 157:991-8
Yarrington, G; Fontwit, K; Figueroa, J P et al. (1986) Reversal of the effects of 4-amino-antipyrine on myometrial and cervical electromyographic activity by PGF2 alpha in the ovariectomized estradiol-replaced non-pregnant ewe. Yale J Biol Med 59:415-24
Pimentel, G; Figueroa, J P; Mitchell, M D et al. (1986) Effect of fetal and maternal intravascular antipyrine infusion on maternal plasma prostaglandin concentrations in the pregnant sheep at 104 to 127 days' gestation. Am J Obstet Gynecol 155:1181-5
Lowe, K C; Gluckman, P D; Jansen, C A et al. (1986) Plasma growth hormone concentration in the chronically catheterized ovine fetus during spontaneous term delivery and premature delivery induced by continuous intravascular infusion of low doses of adrenocorticotropin or cortisol to the fetus. Am J Obstet Gynecol 154:420-3
Yarrington, G; Figueroa, J P; Massmann, A et al. (1986) An analysis of the characteristics of the electromyogram recorded from the mesometrium in the ovariectomized nonpregnant ewe and its similarities with and differences from the electromyogram obtained from the myometrium: the effect of estrogens. Am J Obstet Gynecol 155:1160-4
Huyler, S E; Butler, W R; Grandis, A et al. (1985) Stimulation of ovine placental lactogen secretion by arachidonic acid. J Endocrinol 106:43-7
Cohen, D; Corbin, J; Figueroa, J P et al. (1985) Inhibition of arachidonic acid metabolism by antipyrine and 4-aminoantipyrine. Am J Obstet Gynecol 153:589-90
Figueroa, J P; Mahan, S; Poore, E R et al. (1985) Characteristics and analysis of uterine electromyographic activity in the pregnant sheep. Am J Obstet Gynecol 151:524-31
Jenkin, G; Jorgensen, G; Thorburn, G D et al. (1985) Induction of premature delivery in sheep following infusion of cortisol to the fetus. I. The effect of maternal administration of progestagens. Can J Physiol Pharmacol 63:500-8