The focus of this proposal is to obtain an understanding of the motor control characteristics of the stereotypic movement disorders of the developmentally disabled, and in particular, those movements associated with tardive dyskinesia. Current characterizations of stereotypic behaviors rely largely on the natural observation of the observer and speculation about the appropriate categorization of movement disorders. It is proposed that a formal kinematic analysis of the movement disorders with subjects under neuroleptic medication and withdrawn from neuroleptic medication conditions and different task constraints will: (1) provide a description of the stereotypic movements that is consonant with movement parameters seen to reflect organizational coordination and control properties of the central nervous system; (2) allow comparison to matched 'normal' subjects on fundamental rhythmic and vocational activities and, while attempting to mimick the performance of stereotypic activities; (3) allow an examination of the effect of psychotropic drugs on the motor control characteristics of movement disorders; (4) provide a formal test of the observer checklist approach to characterizing stereotypic movements. The findings from the proposed experiments should provide a screening test than, for example DIS-Co, to assess tardive dyskinesia in various populations of mentally retarded people.
| Vaillancourt, David E; Larsson, Lars; Newell, Karl M (2002) Time-dependent structure in the discharge rate of human motor units. Clin Neurophysiol 113:1325-38 |
| Vaillancourt, David E; Slifkin, Andrew B; Newell, Karl M (2002) Inter-digit individuation and force variability in the precision grip of young, elderly, and Parkinson's disease participants. Motor Control 6:113-28 |
| Vaillancourt, David E; Newell, Karl M (2002) Changing complexity in human behavior and physiology through aging and disease. Neurobiol Aging 23:1-11 |
| Vaillancourt, David E; Newell, Karl M (2002) Complexity in aging and disease: response to commentaries. Neurobiol Aging 23:27-9 |
| Newell, Karl M; Challis, John H; Boros, Rhonda L et al. (2002) Further evidence on the dynamics of self-injurious behaviors: impact forces and limb motions. Am J Ment Retard 107:60-8 |
| Vaillancourt, D E; Slifkin, A B; Newell, K M (2001) Intermittency in the visual control of force in Parkinson's disease. Exp Brain Res 138:118-27 |
| Vaillancourt, D E; Slifkin, A B; Newell, K M (2001) Regularity of force tremor in Parkinson's disease. Clin Neurophysiol 112:1594-603 |
| Vaillancourt, D E; Slifkin, A B; Newell, K M (2001) Visual control of isometric force in Parkinson's disease. Neuropsychologia 39:1410-8 |
| Slifkin, A B; Vaillancourt, D E; Newell, K M (2000) Intermittency in the control of continuous force production. J Neurophysiol 84:1708-18 |
| Slifkin, A B; Newell, K M (2000) Variability and noise in continuous force production. J Mot Behav 32:141-50 |
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