Abstract

The long-term objectives of the research proposed are to determine the biological consequences of exposure to ultrasound on mammalian development. The studies proposed fall into two groups, the first being to evaluate the effects of ultrasound exposure of the ovary, by means of assessing preimplantation embryonic development in the mouse. Using this model, experiments have been designed to examine the effects of different levels of ultrasound on cell division, DNA synthesis, protein synthesis and the appearance of temporally-regulated cell surface molecules in the early embryo. The second group of experiments is concerned with the biological consequences to the post-implantation embryo following intrauterine exposure to ultrasound. They will test the hypothesis that ultrasound can cause irreversible damage to the developing central nervous system. Experiments have been designed to characterize CNS damage resulting from ultrasound exposure, to determine if damage is reversible, to demonstrate stage-related susceptibility to ultrasound and to determine whether effects are cumulative.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD021676-03
Application #
3320675
Study Section
(SSS)
Project Start
1987-07-01
Project End
1991-06-30
Budget Start
1989-07-01
Budget End
1990-06-30
Support Year
3
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
Temple University
Department
Type
Schools of Medicine
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19122

  Publications

Margulies, N; Abraham, V; Way, J S et al. (1992) Effect of ultrasound on the neonatal rat brain. Ultrasound Med Biol 18:459-64
Margulies, N; Abraham, V; Way, J S et al. (1991) Reversible biochemical changes in the developing rat central nervous system following ultrasound exposure. Ultrasound Med Biol 17:383-90
Muscarella, L F; Vasthare, U; Tuma, R F et al. (1991) Effect of ultrasound on regional cerebral blood flow in neonatal rats. Ultrasound Med Biol 17:893-9
Rao, G S; Abraham, V; Fink, B A et al. (1990) Biochemical changes in the developing rat central nervous system due to hyperthermia. Teratology 41:327-32
Abraham, V; Ziskin, M C; Heyner, S (1989) Temperature elevation in the rat fetus due to ultrasound exposure. Ultrasound Med Biol 15:443-9
Miller, M W; Ziskin, M C (1989) Biological consequences of hyperthermia. Ultrasound Med Biol 15:707-22
Ziskin, M C; Petitti, D B (1988) Epidemiology of human exposure to ultrasound: a critical review. Ultrasound Med Biol 14:91-6