Recent work from the Principle Investigator's laboratory suggests that previous animal research has greatly underestimated the role adequate diet early in life plays in cognitive development. The general aim of the proposed research is to clarify that role. To do this a model of """"""""normal"""""""" cognitive development in the rat will be employed to assess the effects of early-life malnutrition (ELM). The specific goals of the proposed research are to identify (a) the kinds of cognitive capacities that are vulnerable during development to the effects of ELM, (b) the major parameters of postnatal ELM that contribute to impaired cognitive development, and (c) to study the effects of prenatal ELM for its effects on cognitive development. It is first important to document the extent ELM impacts on cognitive development and to thoroughly understand the parameters that determine its influence. With this information, we hope to develop dietary and pharmacological procedures that may lessen the impact of ELM. Since a large portion of the world's children suffer nutritional deficits early in life, an understanding of how inadequate diets alter cognitive development is much needed.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD023337-03
Application #
3323465
Study Section
Psychobiology and Behavior Research Review Committee (BBP)
Project Start
1987-09-01
Project End
1991-02-28
Budget Start
1989-09-01
Budget End
1991-02-28
Support Year
3
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Colorado at Boulder
Department
Type
Schools of Arts and Sciences
DUNS #
City
Boulder
State
CO
Country
United States
Zip Code
80309
Ahmed, Amina; Li, Jianpin; Shiloach, Yossi et al. (2006) Safety and immunogenicity of Escherichia coli O157 O-specific polysaccharide conjugate vaccine in 2-5-year-old children. J Infect Dis 193:515-21
Castro, C A; Rudy, J W (1993) Impaired short-term memory resulting from postnatal undernutrition is attenuated by physostigmine. Behav Neural Biol 60:282-5
Carew, M B; Rudy, J W (1991) Multiple functions of context during conditioning: a developmental analysis. Dev Psychobiol 24:191-209
Rudy, J W; Castro, C A (1990) Undernutrition during the brain growth period of the rat significantly delays the development of processes mediating Pavlovian trace conditioning. Behav Neural Biol 53:307-20
Castro, C A; Paylor, R; Moye, T B et al. (1990) The cholinergic agent physostigmine enhances short-term-memory-based performance in the developing rat. Behav Neurosci 104:390-3
Paylor, R; Rudy, J W (1990) Cholinergic receptor blockade can impair the rat's performance on both the place learning and cued versions of the Morris water task: the role of age and pool wall brightness. Behav Brain Res 36:79-90
Castro, C A; Tracy, M; Rudy, J W (1989) Early-life undernutrition impairs the development of the learning and short-term memory processes mediating performance in a conditional-spatial discrimination task. Behav Brain Res 32:255-64
Castro, C A; Rudy, J W (1989) Early-life malnutrition impairs the performance of both young and adult rats on visual discrimination learning tasks. Dev Psychobiol 22:15-28