Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
3R01HD023338-02S1
Application #
3323467
Study Section
Neurology A Study Section (NEUA)
Project Start
1987-09-01
Project End
1989-08-31
Budget Start
1989-04-01
Budget End
1989-08-31
Support Year
2
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Worcester Foundation for Biomedical Research
Department
Type
DUNS #
City
Shrewsbury
State
MA
Country
United States
Zip Code
01545
Attardi, Barbara J; Marck, Brett T; Matsumoto, Alvin M et al. (2011) Long-term effects of dimethandrolone 17ýý-undecanoate and 11ýý-methyl-19-nortestosterone 17ýý-dodecylcarbonate on body composition, bone mineral density, serum gonadotropins, and androgenic/anabolic activity in castrated male rats. J Androl 32:183-92
Attardi, Barbara J; Engbring, Jean A; Gropp, David et al. (2011) Development of dimethandrolone 17beta-undecanoate (DMAU) as an oral male hormonal contraceptive: induction of infertility and recovery of fertility in adult male rabbits. J Androl 32:530-40
Attardi, Barbara J; Koduri, Sailaja; Hild, Sheri A (2010) Relative progestational and androgenic activity of four progestins used for male hormonal contraception assessed in vitro in relation to their ability to suppress LH secretion in the castrate male rat. Mol Cell Endocrinol 328:16-21
Attardi, Barbara J; Page, Stephanie T; Hild, Sheri A et al. (2010) Mechanism of action of bolandiol (19-nortestosterone-3beta,17beta-diol), a unique anabolic steroid with androgenic, estrogenic, and progestational activities. J Steroid Biochem Mol Biol 118:151-61
Attardi, Barbara J; Hild, Sheri A; Koduri, Sailaja et al. (2010) The potent synthetic androgens, dimethandrolone (7?,11?-dimethyl-19-nortestosterone) and 11?-methyl-19-nortestosterone, do not require 5?-reduction to exert their maximal androgenic effects. J Steroid Biochem Mol Biol 122:212-8
Hild, Sheri Ann; Attardi, Barbara J; Koduri, Sailaja et al. (2010) Effects of synthetic androgens on liver function using the rabbit as a model. J Androl 31:472-81
Tash, Joseph S; Attardi, Barbara; Hild, Sheri A et al. (2008) A novel potent indazole carboxylic acid derivative blocks spermatogenesis and is contraceptive in rats after a single oral dose. Biol Reprod 78:1127-38
Koduri, Sailaja; Hild, Sheri Ann; Pessaint, Laurent et al. (2008) Mechanism of action of l-CDB-4022, a potential nonhormonal male contraceptive, in the seminiferous epithelium of the rat testis. Endocrinology 149:1850-60
Attardi, Barbara J; Pham, Trung C; Radler, Lisa C et al. (2008) Dimethandrolone (7alpha,11beta-dimethyl-19-nortestosterone) and 11beta-methyl-19-nortestosterone are not converted to aromatic A-ring products in the presence of recombinant human aromatase. J Steroid Biochem Mol Biol 110:214-22
Hild, Sheri Ann; Reel, Jerry R; Dykstra, Michael J et al. (2007) Acute adverse effects of the indenopyridine CDB-4022 on the ultrastructure of sertoli cells, spermatocytes, and spermatids in rat testes: comparison to the known sertoli cell toxicant Di-n-pentylphthalate (DPP). J Androl 28:621-9

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