Gene-Trap Approaches to Mammalian Development

Rossant, Janet

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
• Type: Research Project (R01)
• Project #: 5R01HD025334-06
• Application #: 2199510
• Study Section: Human Embryology and Development Subcommittee 1 (HED)
• Project Start: 1989-08-01
• Project End: 1996-03-31
• Budget Start: 1995-04-01
• Budget End: 1996-03-31
• Support Year: 6
• Fiscal Year: 1995

Institution

• Name: MT Sinai Hosp-Samuel Lunenfeld Research Institute
• City: Toronto
• State: ON
• Country: Canada
• Zip Code: M5 3-L9

Publications

Gasca, S; Hill, D P; Klingensmith, J et al. (1995) Characterization of a gene trap insertion into a novel gene, cordon-bleu, expressed in axial structures of the gastrulating mouse embryo. Dev Genet 17:141-54

Wurst, W; Rossant, J; Prideaux, V et al. (1995) A large-scale gene-trap screen for insertional mutations in developmentally regulated genes in mice. Genetics 139:889-99

Soininen, R; Schoor, M; Henseling, U et al. (1992) The mouse Enhancer trap locus 1 (Etl-1): a novel mammalian gene related to Drosophila and yeast transcriptional regulator genes. Mech Dev 39:111-23

Skarnes, W C; Auerbach, B A; Joyner, A L (1992) A gene trap approach in mouse embryonic stem cells: the lacZ reported is activated by splicing, reflects endogenous gene expression, and is mutagenic in mice. Genes Dev 6:903-18

Joyner, A L; Herrup, K; Auerbach, B A et al. (1991) Subtle cerebellar phenotype in mice homozygous for a targeted deletion of the En-2 homeobox. Science 251:1239-43