Paracrine Role of Ovarian Transforming Growth Factor-B

Magoffin, Denis A.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
• Type: Research Project (R01)
• Project #: 5R01HD028953-03
• Application #: 2201439
• Study Section: Reproductive Endocrinology Study Section (REN)
• Project Start: 1992-07-01
• Project End: 1997-06-30
• Budget Start: 1994-07-01
• Budget End: 1997-06-30
• Support Year: 3
• Fiscal Year: 1994

Institution

• Name: Cedars-Sinai Medical Center
• DUNS #: 075307785
• City: Los Angeles
• State: CA
• Country: United States
• Zip Code: 90048

Publications

Zachow, R J; Weitsman, S R; Magoffin, D A (1997) Hepatocyte growth factor regulates ovarian theca-interstitial cell differentiation and androgen production. Endocrinology 138:691-7

Agarwal, S K; Judd, H L; Magoffin, D A (1996) A mechanism for the suppression of estrogen production in polycystic ovary syndrome. J Clin Endocrinol Metab 81:3686-91

Fournet, N; Weitsman, S R; Zachow, R J et al. (1996) Transforming growth factor-beta inhibits ovarian 17 alpha-hydroxylase activity by a direct noncompetitive mechanism. Endocrinology 137:166-74

Magoffin, D A; Hubert-Leslie, D; Zachow, R J (1995) Estradiol-17 beta, insulin-like growth factor-I, and luteinizing hormone inhibit secretion of transforming growth factor beta by rat ovarian theca-interstitial cells. Biol Reprod 53:627-35

Zachow, R J; Magoffin, D A (1995) Granulosa cell modulation of luteinizing hormone-dependent androgen production by ovarian theca-interstitial cells: a temporal switch from suppression to augmentation stimulated by follicle-stimulating hormone in vitro. Biol Reprod 53:758-65