Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD032040-03
Application #
2204938
Study Section
Biochemistry Study Section (BIO)
Project Start
1994-07-15
Project End
1998-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Physiology
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Lee, H C (1998) Calcium signaling by cyclic ADP-ribose and NAADP. A decade of exploration. Cell Biochem Biophys 28:1-17
Graeff, R M; Franco, L; De Flora, A et al. (1998) Cyclic GMP-dependent and -independent effects on the synthesis of the calcium messengers cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate. J Biol Chem 273:118-25
Graeff, R M; Walseth, T F; Lee, H C (1997) Radioimmunoassay for measuring endogenous levels of cyclic ADP-ribose in tissues. Methods Enzymol 280:230-41
Munshi, C; Lee, H C (1997) High-level expression of recombinant Aplysia ADP-ribosyl cyclase in offhia pastoris by fermentation. Protein Expr Purif 11:104-10
Munshi, C B; Fryxell, K B; Lee, H C et al. (1997) Large-scale production of human CD38 in yeast by fermentation. Methods Enzymol 280:318-30
De Flora, A; Guida, L; Franco, L et al. (1997) CD38 and ADP-ribosyl cyclase catalyze the synthesis of a dimeric ADP-ribose that potentiates the calcium-mobilizing activity of cyclic ADP-ribose. J Biol Chem 272:12945-51
Walseth, T F; Aarhus, R; Gurnack, M E et al. (1997) Preparation of cyclic ADP-ribose antagonists and caged cyclic ADP-ribose. Methods Enzymol 280:294-305
Lee, H C; Graeff, R M; Walseth, T F (1997) ADP-ribosyl cyclase and CD38. Multi-functional enzymes in Ca+2 signaling. Adv Exp Med Biol 419:411-9
Walseth, T F; Wong, L; Graeff, R M et al. (1997) Bioassay for determining endogenous levels of cyclic ADP-ribose. Methods Enzymol 280:287-94
Lee, H C; Aarhus, R; Gee, K R et al. (1997) Caged nicotinic acid adenine dinucleotide phosphate. Synthesis and use. J Biol Chem 272:4172-8

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