Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
1R01HD033000-01A1
Application #
2206336
Study Section
Reproductive Biology Study Section (REB)
Project Start
1996-05-01
Project End
2000-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Population Council
Department
Type
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10017
Latif, Syed A; Shen, Mae; Ge, Ren-Shan et al. (2011) Role of 11*-OH-C(19) and C(21) steroids in the coupling of 11*-HSD1 and 17*-HSD3 in regulation of testosterone biosynthesis in rat Leydig cells. Steroids 76:682-9
Zheng, Rong; Horiguchi, Akio; Iida, Katsuyuki et al. (2010) Neutral endopeptidase is a myristoylated protein. Mol Cell Biochem 335:173-80
Lee, June G; Zheng, Rong; McCafferty-Cepero, Jennifer M et al. (2009) Endothelin-1 enhances the expression of the androgen receptor via activation of the c-myc pathway in prostate cancer cells. Mol Carcinog 48:141-9
Hu, Guo-Xin; Lin, Han; Sottas, Chantal M et al. (2008) Inhibition of 11beta-hydroxysteroid dehydrogenase enzymatic activities by glycyrrhetinic acid in vivo supports direct glucocorticoid-mediated suppression of steroidogenesis in Leydig cells. J Androl 29:345-51
Ge, Renshan; Chen, Guorong; Hardy, Matthew P (2008) The role of the Leydig cell in spermatogenic function. Adv Exp Med Biol 636:255-69
Hu, Guo-Xin; Lian, Qing-Quan; Lin, Han et al. (2008) Rapid mechanisms of glucocorticoid signaling in the Leydig cell. Steroids 73:1018-24
Lee, J G; Ge, R; Hardy, D O et al. (2008) Modulation of 11beta-hydroxysteroid dehydrogenase expression by bombesin: a possible mechanism for glucocorticoid resistance in androgen independent prostate cancer. Horm Metab Res 40:772-8
Chen, Guo-Rong; Ge, Ren-Shan; Lin, Han et al. (2007) Development of a cryopreservation protocol for Leydig cells. Hum Reprod 22:2160-8
Morris, D J; Latif, S A; Hardy, M P et al. (2007) Endogenous inhibitors (GALFs) of 11beta-hydroxysteroid dehydrogenase isoforms 1 and 2: derivatives of adrenally produced corticosterone and cortisol. J Steroid Biochem Mol Biol 104:161-8
Weissman, Ben A; Sottas, Chantal M; Zhou, Ping et al. (2007) Testosterone production in mice lacking inducible nitric oxide synthase expression is sensitive to restraint stress. Am J Physiol Endocrinol Metab 292:E615-20

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