Endometriosis affects up to 10% of women of reproductive age in the U.S. with chronic pelvic pain, dysmenorrhea, and probable increased risk of infertility. Although the disease has been identified as a top research priority by the National Institutes of Health, the etiology is still uncertain, and few modifiable risk factors have been identified. Past epidemiologic research has been inconclusive about the impact of reproductive or contraceptive history on the development of endometriosis. Most studies of these risk factors have been limited by using cases identified at infertility surgery, as these women may be atypical of all endometriosis cases in terms of reproductive and contraceptive history. We propose a population-based case-control study of endometriosis among the entire population of reproductive-age women enrolled in an HMO in western Washington State to test the hypothesis that spontaneous abortion and induced abortion may increase risk of endometriosis, taking into account possible hormonal and immunological influences. The associations between endometriosis and delayed childbearing and various types of contraception will be investigated as well. All 18-44 year old enrollees of Group Health Cooperative of Puget Sound (GHC) diagnosed with endometriosis by surgery, and a portion of those diagnosed by physical examination or ultrasound examination alone between August l, 1996 and April 30, 2001 will be identified and invited to participate (approximately 750 women of all races). Cases will be selected using computerized records, and eligibility verified by medical records. Controls randomly selected from computerized enrollment files will be frequency matched to cases on age and primary care clinic region. Data will be obtained from cases and controls by in-person interview, and anthropometric measurement; and linked with the GHC computerized pharmacy database. Subjects will be interviewed regarding their reproductive and contraceptive histories; including spontaneous and induced abortions, stillbirths, livebirths, use of hormonal contraceptives, intrauterine devices, and sterilization procedures; menstrual history; infertility history; and other risk factors for endometriosis.
| Upson, Kristen; Sathyanarayana, Sheela; Scholes, Delia et al. (2015) Early-life factors and endometriosis risk. Fertil Steril 104:964-971.e5 |
| Upson, Kristen; Sathyanarayana, Sheela; De Roos, Anneclaire J et al. (2014) A population-based case-control study of urinary bisphenol A concentrations and risk of endometriosis. Hum Reprod 29:2457-64 |
| Upson, Kristen; De Roos, Anneclaire J; Thompson, Mary Lou et al. (2013) Organochlorine pesticides and risk of endometriosis: findings from a population-based case-control study. Environ Health Perspect 121:1319-24 |
| Upson, Kristen; Sathyanarayana, Sheela; De Roos, Anneclaire J et al. (2013) Phthalates and risk of endometriosis. Environ Res 126:91-7 |
| Trabert, Britton; Schwartz, Stephen M; Peters, Ulrike et al. (2011) Genetic variation in the sex hormone metabolic pathway and endometriosis risk: an evaluation of candidate genes. Fertil Steril 96:1401-1406.e3 |
| Trabert, Britton; Peters, Ulrike; De Roos, Anneclaire J et al. (2011) Diet and risk of endometriosis in a population-based case-control study. Br J Nutr 105:459-67 |
| Trabert, Britton; De Roos, Anneclaire J; Schwartz, Stephen M et al. (2010) Non-dioxin-like polychlorinated biphenyls and risk of endometriosis. Environ Health Perspect 118:1280-5 |
| Marino, Jennifer L; Holt, Victoria L; Chen, Chu et al. (2009) Lifetime occupational history and risk of endometriosis. Scand J Work Environ Health 35:233-40 |
| Marino, Jennifer L; Holt, Victoria L; Chen, Chu et al. (2008) Shift work, hCLOCK T3111C polymorphism, and endometriosis risk. Epidemiology 19:477-84 |
