Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD035396-02
Application #
6072732
Study Section
Program Officer
Henken, Deborah B
Project Start
1997-04-01
Project End
2001-03-31
Budget Start
Budget End
Support Year
2
Fiscal Year
1999
Total Cost
Indirect Cost
Finnell, Richard H; Waes, Janee Gelineau-van; Eudy, James D et al. (2002) Molecular basis of environmentally induced birth defects. Annu Rev Pharmacol Toxicol 42:181-208
Gefrides, Lisa A; Bennett, Gregory D; Finnell, Richard H (2002) Effects of folate supplementation on the risk of spontaneous and induced neural tube defects in Splotch mice. Teratology 65:63-9
Wlodarczyk, B; Spiegelstein, O; Gelineau-van Waes, J et al. (2001) Arsenic-induced congenital malformations in genetically susceptible folate binding protein-2 knockout mice. Toxicol Appl Pharmacol 177:238-46
Spiegelstein, O; Eudy, J D; Finnell, R H (2000) Identification of two putative novel folate receptor genes in humans and mouse. Gene 258:117-25
Barber, R C; Lammer, E J; Shaw, G M et al. (1999) The role of folate transport and metabolism in neural tube defect risk. Mol Genet Metab 66:1-9
Piedrahita, J A; Oetama, B; Bennett, G D et al. (1999) Mice lacking the folic acid-binding protein Folbp1 are defective in early embryonic development. Nat Genet 23:228-32
Barber, R C; Bennett, G D; Greer, K A et al. (1999) Expression patterns of folate binding proteins one and two in the developing mouse embryo. Mol Genet Metab 66:31-9
Barber, R C; Shaw, G M; Lammer, E J et al. (1998) Lack of association between mutations in the folate receptor-alpha gene and spina bifida. Am J Med Genet 76:310-7