This proposal intends to follow a group of 117 adolescents with ADHD and a comparable control group for as well as over 100 of their siblings, subjects already followed for five years, for an additional five years. Given the mean age of the sample, this study will provide information about ADHD as subjects mature from adolescence into young adult life. These subjects will be assessed on six domains: psychopathology, cognitive-neuropsychological functioning, school dysfunction, adaptive functioning, treatment interventions and psychosocial adversity. A variety of measures are included in the assessment of each domain. Analytic methods address six issues: variable age of onset of psychiatric illness; nonindependence of observations within families and between time periods; effects of treatment; integration of information across multiple informants; effects of confounding variables; wide age range of the sample at baseline. The investigators will test three general hypotheses: prediction of outcome based on baseline ADHD (or sibling of ADHD); prediction of outcome based on comorbidity; prediction of outcome and comorbidity based on DSM-IV subtypes.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD036317-04
Application #
6387937
Study Section
Human Development and Aging Subcommittee 3 (HUD)
Program Officer
Haverkos, Lynne
Project Start
1998-04-01
Project End
2003-03-31
Budget Start
2001-04-01
Budget End
2002-03-31
Support Year
4
Fiscal Year
2001
Total Cost
$445,879
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
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