Abstract

The investigator will attempt to determine how cells respond to different doses of inducers such as activin, a TGF-beta superfamily member (TGF-SM) Using a variety of readouts he plans to determine how individual cells respond to different concentrations of TGF-SMs. He also proposes to determine the effects on different processes in Xenopus development when different TGF-SM pathways are activated or blocked.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD036345-03
Application #
6182366
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Program Officer
Klein, Steven
Project Start
1998-07-01
Project End
2003-06-30
Budget Start
2000-07-01
Budget End
2001-06-30
Support Year
3
Fiscal Year
2000
Total Cost
$246,616
Indirect Cost

  Institution

Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02215

  Publications

Green, Jeremy B A; Dominguez, Isabel; Davidson, Lance A (2004) Self-organization of vertebrate mesoderm based on simple boundary conditions. Dev Dyn 231:576-81
Green, Jeremy B A (2004) Lkb1 and GSK3-beta: kinases at the center and poles of the action. Cell Cycle 3:12-4
Ossipova, Olga; Bardeesy, Nabeel; DePinho, Ronald A et al. (2003) LKB1 (XEEK1) regulates Wnt signalling in vertebrate development. Nat Cell Biol 5:889-94
Ossipova, Olga; He, Xi; Green, Jeremy (2002) Molecular cloning and developmental expression of Par-1/MARK homologues XPar-1A and XPar-1B from Xenopus laevis. Gene Expr Patterns 2:145-50
Ossipova, Olga; He, Xi; Green, Jeremy (2002) Molecular cloning and developmental expression of Par-1/MARK homologues XPar-1A and XPar-1B from Xenopus laevis. Mech Dev 119 Suppl 1:S143-8
Kavka, A I; Green, J B (2000) Evidence for dual mechanisms of mesoderm establishment in Xenopus embryos. Dev Dyn 219:77-83