Abstract

Fibrillins are major components of microfibrils of the extracellular matrix. They contain a LTBP repeat, found in proteins involved in TBF signaling specifically facilitating secretion or release. Besides a potential role in modulating TBFs, fibrillin microfibrils may serve mechanical roles. Dr. Keller will test specific hypotheses regarding the possible role of fibrillin in establishing the notochord/somite boundary, and in convergence and extension movements in Xenopus during gastrulation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD036426-03
Application #
6182337
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Program Officer
Klein, Steven
Project Start
1998-05-04
Project End
2003-04-30
Budget Start
2000-05-01
Budget End
2001-04-30
Support Year
3
Fiscal Year
2000
Total Cost
$207,465
Indirect Cost

  Institution

Name
University of Virginia
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
001910777
City
Charlottesville
State
VA
Country
United States
Zip Code
22904

  Publications

Rolo, Ana; Skoglund, Paul; Keller, Ray (2009) Morphogenetic movements driving neural tube closure in Xenopus require myosin IIB. Dev Biol 327:327-38
Skoglund, Paul; Rolo, Ana; Chen, Xuejun et al. (2008) Convergence and extension at gastrulation require a myosin IIB-dependent cortical actin network. Development 135:2435-44
Davidson, Lance A; Dzamba, Bette D; Keller, Ray et al. (2008) Live imaging of cell protrusive activity, and extracellular matrix assembly and remodeling during morphogenesis in the frog, Xenopus laevis. Dev Dyn 237:2684-92
Skoglund, Paul; Keller, Ray (2007) Xenopus fibrillin regulates directed convergence and extension. Dev Biol 301:404-16
Davidson, Lance A; Marsden, Mungo; Keller, Raymond et al. (2006) Integrin alpha5beta1 and fibronectin regulate polarized cell protrusions required for Xenopus convergence and extension. Curr Biol 16:833-44
Shook, David R; Majer, Christina; Keller, Ray (2004) Pattern and morphogenesis of presumptive superficial mesoderm in two closely related species, Xenopus laevis and Xenopus tropicalis. Dev Biol 270:163-85
Green, Jeremy B A; Dominguez, Isabel; Davidson, Lance A (2004) Self-organization of vertebrate mesoderm based on simple boundary conditions. Dev Dyn 231:576-81
Davidson, Lance A; Keller, Raymond; DeSimone, Douglas W (2004) Assembly and remodeling of the fibrillar fibronectin extracellular matrix during gastrulation and neurulation in Xenopus laevis. Dev Dyn 231:888-95
Goto, Toshiyasu; Keller, Ray (2002) The planar cell polarity gene strabismus regulates convergence and extension and neural fold closure in Xenopus. Dev Biol 247:165-81
Shook, David R; Majer, Christina; Keller, Ray (2002) Urodeles remove mesoderm from the superficial layer by subduction through a bilateral primitive streak. Dev Biol 248:220-39

Showing the most recent 10 out of 11 publications