The investigators propose a prospective study of 1000 low income and minority gravidas from Camden, NJ, to test the hypothesis that risk of poor pregnancy outcome is associated with an increased level of oxidative stress. They propose to measure oxidative stress, iron and iron-associated compounds, and antioxidant status at entry to care, 20 and 28 weeks gestation during pregnancy. Infant birth weight and the frequency of other poor pregnancy outcomes in the study population will serve as the outcomes. The primary objective is to determine the prognostic importance of indices for oxidative stress, specifically isoprostane 8-iso-PGF2a and 8-hydroxydeoyguanosine excretion, on low birth weight and other poor pregnancy outcomes. Secondary outcomes are: (a) to determine the prognostic importance of indices for maternal antioxidant status (total, endogenous, exogenous) on low birth weight and other poor pregnancy outcomes; (b) to determine whether indices for oxidative stress (isoprostane 8-iso-PGF2a and 8-hydroxydeoyguanosine excretion) are related to serum cotinine (a biomarker for smoking), diet (antioxidant and trace-mineral intake), ethnicity and other maternal characteristics during pregnancy; (c) to determine whether indices of oxidative stress during pregnancy are associated with biomarkers for maternal iron status and associated compounds (serum ferritin, hemoglobin, serum iron, total iron binding capacity, transferrin saturation) and 2,3 DPG.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD038329-05
Application #
6776990
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Program Officer
Ilekis, John V
Project Start
2000-09-01
Project End
2006-08-31
Budget Start
2004-09-01
Budget End
2005-08-31
Support Year
5
Fiscal Year
2004
Total Cost
$963,015
Indirect Cost
Name
University of Medicine & Dentistry of NJ
Department
Obstetrics & Gynecology
Type
Schools of Osteopathy
DUNS #
140757589
City
Stratford
State
NJ
Country
United States
Zip Code
08084
Scholl, Theresa O; Chen, Xinhua; Stein, T Peter (2014) Maternal calcium metabolic stress and fetal growth. Am J Clin Nutr 99:918-25
Chen, Xinhua; Scholl, Theresa O (2014) Maternal biomarkers of endothelial dysfunction and preterm delivery. PLoS One 9:e85716
Scholl, Theresa O; Chen, Xinhua; Stein, T Peter (2013) Vitamin D, secondary hyperparathyroidism, and preeclampsia. Am J Clin Nutr 98:787-93
Scholl, Theresa O; Chen, Xinhua; Stein, Peter (2012) Maternal vitamin D status and delivery by cesarean. Nutrients 4:319-30
Scholl, Theresa O; Chen, Xinhua; Goldberg, Gary S et al. (2011) Maternal diet, C-reactive protein, and the outcome of pregnancy. J Am Coll Nutr 30:233-40
Scholl, Theresa O (2011) Maternal iron status: relation to fetal growth, length of gestation, and iron endowment of the neonate. Nutr Rev 69 Suppl 1:S23-9
Chen, Xinhua; Scholl, Theresa O; Leskiw, Maria et al. (2010) Differences in maternal circulating fatty acid composition and dietary fat intake in women with gestational diabetes mellitus or mild gestational hyperglycemia. Diabetes Care 33:2049-54
Scholl, Theresa O; Chen, Xinhua (2009) Vitamin D intake during pregnancy: association with maternal characteristics and infant birth weight. Early Hum Dev 85:231-4
Chen, Xinhua; Scholl, Theresa O (2008) Association of elevated free fatty acids during late pregnancy with preterm delivery. Obstet Gynecol 112:297-303
Peter Stein, T; Scholl, Theresa O; Schluter, Margaret D et al. (2008) Oxidative stress early in pregnancy and pregnancy outcome. Free Radic Res 42:841-8

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