Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD044056-02
Application #
6697048
Study Section
Cell Development and Function Integrated Review Group (CDF)
Program Officer
Javois, Lorette Claire
Project Start
2003-01-13
Project End
2007-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
2
Fiscal Year
2004
Total Cost
$344,250
Indirect Cost
Name
Washington University
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Morimoto, Mitsuru; Kopan, Raphael (2009) rtTA toxicity limits the usefulness of the SP-C-rtTA transgenic mouse. Dev Biol 325:171-8
Riesenberg, Amy N; Liu, Zhenyi; Kopan, Raphael et al. (2009) Rbpj cell autonomous regulation of retinal ganglion cell and cone photoreceptor fates in the mouse retina. J Neurosci 29:12865-77
Ong, Chin-Tong; Sedy, John R; Murphy, Kenneth M et al. (2008) Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisition. PLoS One 3:e2823
Demehri, Shadmehr; Liu, Zhenyi; Lee, Jonghyeob et al. (2008) Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity. PLoS Biol 6:e123
Bai, Shuting; Kopan, Raphael; Zou, Wei et al. (2008) NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells. J Biol Chem 283:6509-18
Hilton, Matthew J; Tu, Xiaolin; Wu, Ximei et al. (2008) Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nat Med 14:306-14
Vooijs, Marc; Ong, Chin-Tong; Hadland, Brandon et al. (2007) Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE. Development 134:535-44
Lee, Jonghyeob; Basak, Jacob M; Demehri, Shadmehr et al. (2007) Bi-compartmental communication contributes to the opposite proliferative behavior of Notch1-deficient hair follicle and epidermal keratinocytes. Development 134:2795-806
Yang, Xudong; Tomita, Taisuke; Wines-Samuelson, Mary et al. (2006) Notch1 signaling influences v2 interneuron and motor neuron development in the spinal cord. Dev Neurosci 28:102-17
Ong, Chin-Tong; Cheng, Hui-Teng; Chang, Li-Wei et al. (2006) Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability. J Biol Chem 281:5106-19

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