This study is designed to elucidate the interrelation and temporal appearance of precursors of metabolic syndrome (MS) in children and adolescents; the role of major epidemiological variables in the development of MS; and the relative contributions of environmental and genetic factors to attained level and longitudinal change in MS precursors. We propose a follow-up study of approximately 2000 twin pairs initially enrolled in 1998-2000 in Anqing, China, when the twins were aged 6-21 years. Available baseline information on the twins includes epidemiologic and dietary data, anthropometric measures (BMI; waist, hip circumferences, Tanner Stage), total and truncal adiposity assessed by dual energy X-ray absorptiometry (DEXA), blood pressure (BP), fasting lipids, fasting and 2-hr OGTT insulin and glucose, and zygosity.
Our specific aims are: (1) To conduct cross-sectional analyses using the existent baseline data in order to describe the distribution and interrelations of MS related phenotypes (anthropometric measures, adiposity, BP, lipids, insulin, glucose) across age, gender, and pubertal stages; examine the association of major epidemiological variables with MS phenotypes using conventional regression, co-twin analysis and multivariate methods; and estimate the heritability of MS phenotypes. (2) To follow up this cohort in order to re-measure all the MS related phenotypes using the same protocols standardized at baseline plus objective physical activity assessment by uniaxial accelerometer. (3) To conduct longitudinal analyses in order to describe the distributions of and interrelations among changes in MS phenotypes across age, gender, and pubertal stages; predict longitudinal changes in MS phenotypes (both as continuous and binary outcomes) using baseline levels and longitudinal changes of important epidemiological variables and MS markers; and estimate the heritability of longitudinal changes in MS phenotypes across age, gender, and pubertal stages. (4) To measure and assess promising but as yet unproven MS markers among MZ co-twins--insulin-like growth factor-1 (IGF-1), androgen, estrogen, testosterone, LH, and FSH; leptin, adiponectin; C-reactive protein (CRP), IL-6, TNF-alpha receptor 2; fibrinogen, factor VII, plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAl-1)-in order to explore cross-sectional and longitudinal correlations of these markers with established MS markers; and assess their utility as predictors of adverse progression in MS phenotypes. Our preliminary data show considerable variations in MS markers within this cohort, even though it is relatively lean. Further, % body fat in this cohort is almost linearly correlated with BP, triglycerides, fasting glucose and insulin without an evidence of threshold; and MS marker abnormality frequency increases markedly during puberty. This study will provide an in-depth cross-sectional and longitudinal investigation of both established and novel MS markers. Furthermore, this large twin cohort will better clarifv the eenetic versus environmental influences on the develooment of MS and its markers.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD049059-04
Application #
7337149
Study Section
Special Emphasis Panel (ZHD1-MCHG-B (33))
Program Officer
Huang, Terry T-K
Project Start
2005-01-01
Project End
2009-12-31
Budget Start
2008-01-01
Budget End
2008-12-31
Support Year
4
Fiscal Year
2008
Total Cost
$374,544
Indirect Cost
Name
Children's Memorial Hospital (Chicago)
Department
Type
DUNS #
074438755
City
Chicago
State
IL
Country
United States
Zip Code
60611
Raghavan, Ramkripa; Riley, Anne W; Volk, Heather et al. (2018) Maternal Multivitamin Intake, Plasma Folate and Vitamin B12 Levels and Autism Spectrum Disorder Risk in Offspring. Paediatr Perinat Epidemiol 32:100-111
Li, Shenghui; Liu, Rong; Arguelles, Lester et al. (2016) Adiposity trajectory and its associations with plasma adipokine levels in children and adolescents-A prospective cohort study. Obesity (Silver Spring) 24:408-16
Yu, Yunxian; Wang, Lijuan; Liu, Hui et al. (2015) Body mass index and waist circumference rather than body adiposity index are better surrogates for body adiposity in a Chinese population. Nutr Clin Pract 30:274-82
Ji, Yuelong; Kong, Xiangyi; Wang, Guoying et al. (2014) Distribution and determinants of plasma homocysteine levels in rural Chinese twins across the lifespan. Nutrients 6:5900-14
Liu, Rong; Christoffel, Katherine Kaufer; Brickman, Wendy J et al. (2014) Do static and dynamic insulin resistance indices perform similarly in predicting pre-diabetes and type 2 diabetes? Diabetes Res Clin Pract 105:245-50
Liu, Rong; Brickman, Wendy J; Christoffel, Katherine K et al. (2012) Association of adiposity trajectories with insulin sensitivity and glycemic deterioration: a longitudinal study of rural Chinese twin adults. Diabetes Care 35:1506-12
Wang, H; Necheles, J; Birne, J S et al. (2012) Association of adipokines with blood pressure in rural Chinese adolescents. J Hum Hypertens 26:493-501
Liu, Rong; Liu, Xin; Arguelles, Lester M et al. (2012) A population-based twin study on sleep duration and body composition. Obesity (Silver Spring) 20:192-9
Wang, Guoying; Arguelles, Lester; Liu, Rong et al. (2011) Tracking blood glucose and predicting prediabetes in Chinese children and adolescents: a prospective twin study. PLoS One 6:e28573
Wang, Hongjian; Zee, Phyllis; Reid, Kathryn et al. (2011) Gender-specific association of sleep duration with blood pressure in rural Chinese adults. Sleep Med 12:693-9

Showing the most recent 10 out of 34 publications