The maturation of mathematical reasoning skills is a hallmark of human cognitive and academic development. Cognitive, developmental, educational and clinical psychologists have provided valuable insights into the complex and dynamic developmental changes in mathematical skills during childhood. The ages between 7 and 10 (grades 2, 3 and 4) represent an important period for the development of mathematical skills. However, very little is currently known about the development of brain systems that mediate mathematical skill acquisition. The overarching goal of our proposal is to investigate the development of mathematical skills in children using a cognitive and systems neuroscience approach, and a longitudinal study design.
The specific aims of this clinical research proposal are to (1) Investigate longitudinal changes in cognitive and brain processes mediating mathematical cognition at grade 4, (2) Investigate longitudinal changes in functional and structural connectivity of brain networks underlying mathematical cognition, and (3) Investigate the cognitive and neural basis of individual differences in mathematical skill development. Our proposed studies will provide important insights into (1) the neural basis of functional specialization for mathematical cognition;(2) the relation between neural changes and changes in working memory, strategy and increased task proficiency;(3) the developmental origins of functional specialization in the posterior parietal cortex;(4) cortical networks and interactions that subserve mathematical task performance at different stages of skill development;and (5) cognitive and neural factors that mediate individual differences in learning. Taken together, this work will provide significant new information on the maturation of brain networks important for mathematical cognition and skill acquisition. This work has the potential to have broad impact on developmental cognitive neuroscience, brain development, and clinical psychology.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
1R01HD057610-01A1
Application #
7533967
Study Section
Cognitive Neuroscience Study Section (COG)
Program Officer
Mann Koepke, Kathy M
Project Start
2009-08-04
Project End
2011-06-30
Budget Start
2009-08-04
Budget End
2010-06-30
Support Year
1
Fiscal Year
2009
Total Cost
$320,276
Indirect Cost
Name
Stanford University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305
Chen, Lang; Bae, Se Ri; Battista, Christian et al. (2018) Positive Attitude Toward Math Supports Early Academic Success: Behavioral Evidence and Neurocognitive Mechanisms. Psychol Sci 29:390-402
Jolles, Dietsje; Supekar, Kaustubh; Richardson, Jennifer et al. (2016) Reconfiguration of parietal circuits with cognitive tutoring in elementary school children. Cortex 83:231-45
Qin, Shaozheng; Duan, Xujun; Supekar, Kaustubh et al. (2016) Large-scale intrinsic functional network organization along the long axis of the human medial temporal lobe. Brain Struct Funct 221:3237-58
Jolles, Dietsje; Wassermann, Demian; Chokhani, Ritika et al. (2016) Plasticity of left perisylvian white-matter tracts is associated with individual differences in math learning. Brain Struct Funct 221:1337-51
Rosenberg-Lee, Miriam; Ashkenazi, Sarit; Chen, Tianwen et al. (2015) Brain hyper-connectivity and operation-specific deficits during arithmetic problem solving in children with developmental dyscalculia. Dev Sci 18:351-72
Iuculano, Teresa; Rosenberg-Lee, Miriam; Richardson, Jennifer et al. (2015) Cognitive tutoring induces widespread neuroplasticity and remediates brain function in children with mathematical learning disabilities. Nat Commun 6:8453
Wu, Sarah S; Willcutt, Erik G; Escovar, Emily et al. (2014) Mathematics achievement and anxiety and their relation to internalizing and externalizing behaviors. J Learn Disabil 47:503-14
Qin, Shaozheng; Young, Christina B; Duan, Xujun et al. (2014) Amygdala subregional structure and intrinsic functional connectivity predicts individual differences in anxiety during early childhood. Biol Psychiatry 75:892-900
Qin, Shaozheng; Cho, Soohyun; Chen, Tianwen et al. (2014) Hippocampal-neocortical functional reorganization underlies children's cognitive development. Nat Neurosci 17:1263-9
Supekar, Kaustubh; Swigart, Anna G; Tenison, Caitlin et al. (2013) Neural predictors of individual differences in response to math tutoring in primary-grade school children. Proc Natl Acad Sci U S A 110:8230-5

Showing the most recent 10 out of 24 publications