Evidence from biometric and molecular studies indicates that genetic factors significantly influence body mass among humans. This has led to recent efforts to identify single nucleotide polymorphisms (SNPs) across to the entire human genome that are associated with adult and adolescent weight. However, all existing genome wide association (GWA) studies of body mass and obesity have focused on main genetic effects rather than interaction effects between genetic and environmental factors. This leads to gene-environment interaction (GxE) studies that focus on environmental factors that moderate genetic main effects. In the event that there are only genetic effects within particular environments (e.g., no main genetic effects), then current GWA models will overlook important genetic influences. Because body mass is strongly influenced by social environmental factors and because genetic associations for body mass are contingent upon social- environmental influences, environmental risk (and protective) factors must be included in the conceptual understandings and methodological approaches to GWA. While GxE studies involving a single genetic variant are increasingly common, no existing work has specifically focused on genome-wide approaches to GxE. Our approach is a fundamentally new way of examining genetic influences on body mass that extends established GWA methods and draws upon established GxE theory.
This project will provide a comprehensive evaluation of the complex gene-by-environment etiology underlying physical body size on the genome-wide scale. Identification of important gene-by-environment interactions contributing to body mass will reveal important biological mechanisms underlying obesity, detect potential targets for pharmaceutical development and identify populations """"""""at risk"""""""".
| Lawrence, Elizabeth M; Hummer, Robert A; Domingue, Benjamin W et al. (2018) Wide educational disparities in young adult cardiovascular health. SSM Popul Health 5:249-256 |
| Wedow, Robbee; Masters, Ryan K; Mollborn, Stefanie et al. (2018) Body size reference norms and subjective weight status: A gender and life course approach. Soc Forces 96:1377-1409 |
| Domingue, Benjamin W; Belsky, Daniel W; Fletcher, Jason M et al. (2018) The social genome of friends and schoolmates in the National Longitudinal Study of Adolescent to Adult Health. Proc Natl Acad Sci U S A 115:702-707 |
| Belsky, Daniel W; Domingue, Benjamin W; Wedow, Robbee et al. (2018) Genetic analysis of social-class mobility in five longitudinal studies. Proc Natl Acad Sci U S A 115:E7275-E7284 |
| Turley, Patrick; Walters, Raymond K; Maghzian, Omeed et al. (2018) Multi-trait analysis of genome-wide association summary statistics using MTAG. Nat Genet 50:229-237 |
| Demmitt, Brittany A; Corley, Robin P; Huibregtse, Brooke M et al. (2017) Genetic influences on the human oral microbiome. BMC Genomics 18:659 |
| Roettger, Michael E; Boardman, Jason D; Harris, Kathleen Mullan et al. (2016) The association between the MAOA 2R genotype and delinquency over time among men: the interactive role of parental closeness and parental incarceration. Crim Justice Behav 43:1076-1094 |
| Domingue, Benjamin W; Wedow, Robbee; Conley, Dalton et al. (2016) Genome-Wide Estimates of Heritability for Social Demographic Outcomes. Biodemography Soc Biol 62:1-18 |
| McQueen, Matthew B; Boardman, Jason D; Domingue, Benjamin W et al. (2015) The National Longitudinal Study of Adolescent to Adult Health (Add Health) sibling pairs genome-wide data. Behav Genet 45:12-23 |
| Wehby, George L; Domingue, Benjamin W; Boardman, Jason D (2015) Prevention, Use of Health Services, and Genes: Implications of Genetics for Policy Formation. J Policy Anal Manage 34:519-36 |
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