While post-concussive symptoms following sports-related concussion are typically transient and resolve spontaneously within two weeks of concussive injury, 14% or more of youth who sustain concussion experience significant morbidity that can persist well beyond the normal disease course. Furthermore, post- concussive symptoms commonly co-occur with affective symptoms including depression and anxiety which when present can prolong recovery from primary post-concussive symptoms. Together, persistent physical and psychological symptoms confer protracted functional impairment and create a significant burden for affected youth, their family, and school. Currently, there are no evidence-based guidelines to inform treatment of persistent post-concussive symptoms in youth and adolescents. In response to the dearth of evidence-based treatment approaches for youth with persistent post- concussive symptoms, we developed a novel collaborative care treatment model that simultaneously targets post-concussive symptoms and co-occurring depression and anxiety. Athletes and their family members receive patient navigator care management services that bridge post-injury care across acute care, specialist and primary care health service delivery sectors, in addition to cognitive behavioral psychotherapy. Patients who remain symptomatic after initial treatment efforts receive stepped-up care that may include psychopharmacologic consultation. We will conduct a randomized comparative effectiveness trial with 200 youth, ages 11-18, suffering from ? 3 post-concussive symptoms at least 1 month after their sports-related injury. Athletes will be randomized to collaborative care (intervention) or post-sports injury care as usual (control group) conditions. We will determine the effectiveness of a stepped-collaborative care intervention model in reducing post-concussive and co-occurring psychological symptoms in youth with persistent post- concussive symptoms after sports-related concussion; examine the effectiveness of the intervention in improving function and health-related quality of life amongst youth with persistent symptoms after sports- related concussion; and explore differences in school performance between groups.

Public Health Relevance

Sports concussion in youth has been recognized as a major public health problem, particularly when symptoms do not resolve in a timley manner. There are currently no treatments that have been tested for youth with a randomzied trial. Our collaborative care health services intervention could accelerate the rate of recovery from persistent post-concussive symptoms and attenuate the degree and duration of disability during adolescence, a critical period for healthy development.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD090230-04
Application #
9852607
Study Section
Health Services Organization and Delivery Study Section (HSOD)
Program Officer
Quatrano, Louis A
Project Start
2017-02-03
Project End
2021-01-31
Budget Start
2020-02-01
Budget End
2021-01-31
Support Year
4
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Seattle Children's Hospital
Department
Type
DUNS #
048682157
City
Seattle
State
WA
Country
United States
Zip Code
98105