This project proposes to address a critical gap in the literature regarding cancer susceptibility testing by examining utilization of genetic counseling and testing, and behavioral and psychosocial responses to the receipt of genetic information among a large, extended African American kindred (K2099) linked to a specific BRCA1 mutation. Information derived from this study may guide clinical interventions that help promote adherence to cancer prevention and screening guidelines for BRCAl mutation carriers and noncarriers and prevent psychosocial dysflmction related to receiving genetic information among families with characteristics similar to K2099. The findings from this study may also be translated into culturally appropriate interventions to promote healthy behaviors and coping. Female BRCA1 mutation carriers have a very high risk of developing breast or ovarian cancer. Male carriers are at an increased risk for prostate cancer and may transmit the BRCA1 mutation to their offspring. A prospective study of approximately 150 members of K2099 and their spouses/partners will be performed over a four year period. Genetic education and counseling will be provided when testing is offered and at the results session. Data will be collected through detailed questionnaires before and after testing on a wide range of behavioral and psychosocial measures.
The specific aims are to: (1) identify predictors of the decision to choose or decline genetic counseling and testing services; (2) examine the attitudes towards BRCA1 testing among spouses/partners of adult female and male kindred members and determine how they influence BRCAl testing decisions; (3) evaluate the effects of genetic counseling and testing for BRCA1 mutations on psychological and social well being of kindred members and their spouses/partners; (4) identify how genetic counseling and testing, and knowledge of BRCA1 mutation carrier status influences utilization of health services and health behaviors among adult women and men; and (5) describe facilitators and barriers to genetic counseling and testing and utilization of screening and preventive measures for BRCA1 mutation-linked cancers.

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Research Project (R01)
Project #
5R01HG002241-04
Application #
6638067
Study Section
Special Emphasis Panel (ZRG1-GNM (01))
Program Officer
Thomson, Elizabeth
Project Start
2000-09-25
Project End
2006-06-30
Budget Start
2003-07-01
Budget End
2006-06-30
Support Year
4
Fiscal Year
2003
Total Cost
$251,710
Indirect Cost
Name
University of Utah
Department
Type
Schools of Nursing
DUNS #
009095365
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Kinney, Anita Yeomans; Gammon, Amanda; Coxworth, James et al. (2010) Exploring attitudes, beliefs, and communication preferences of Latino community members regarding BRCA1/2 mutation testing and preventive strategies. Genet Med 12:105-15
Kinney, Anita Y; Coxworth, James E; Simonson, Sara E et al. (2009) Religiosity, spirituality, and psychological distress in African-Americans at risk for having a hereditary cancer predisposing gene mutation. Am J Med Genet C Semin Med Genet 151C:13-21
Gullatte, Mary Magee; Hardin, Pamela; Kinney, Anita et al. (2009) Religious beliefs and delay in breast cancer diagnosis for self-detected breast changes in African-American women. J Natl Black Nurses Assoc 20:25-35
Ellington, Lee; Maxwel, Amiee; Baty, Bonnie J et al. (2007) Genetic counseling communication with an African American BRCA1 kindred. Soc Sci Med 64:724-34
Kinney, Anita Yeomans; Simonsen, Sara Ellis; Baty, Bonnie Jeanne et al. (2006) Risk reduction behaviors and provider communication following genetic counseling and BRCA1 mutation testing in an African American kindred. J Genet Couns 15:293-305
Kinney, Anita Yeomans; Simonsen, Sara Ellis; Baty, Bonnie Jeanne et al. (2006) Acceptance of genetic testing for hereditary breast ovarian cancer among study enrollees from an African American kindred. Am J Med Genet A 140:813-26
Baty, Bonnie J; Dudley, William N; Musters, Adrian et al. (2006) Uncertainty in BRCA1 cancer susceptibility testing. Am J Med Genet C Semin Med Genet 142C:241-50
Kinney, Anita Yeomans; Bloor, Lindsey E; Mandal, Diptasri et al. (2005) The impact of receiving genetic test results on general and cancer-specific psychologic distress among members of an African-American kindred with a BRCA1 mutation. Cancer 104:2508-16