We propose a series of clinical trials in the management and prevention of arterial and venous thromboembolism including investigations into pathophysiology and the pharmocology of new anti-thrombotic drugs. The trials included 1). Assessment of intermittent external pneumatic compression of the legs to prevent pulmonary embolism in urologic patients. 2). Evaluation in neurosurgical patients of a hemodynamically optimized system of external pneumatic compression to prevent venous thromboembolism. 3). Investigation in full dose therapy of established thromboembolism of a low molecular weight heparin fraction with limited antithrombin activity but potent anti Xa activity in fractures of the hip. 4). Examination of safety and efficacy of a new radiographic contrast agent in phlebography. 5). Investigation of an inhibitor of thromboxane synthesis in long term patency of arterial by-pass grafts.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL013754-15
Application #
3334693
Study Section
Surgery and Bioengineering Study Section (SB)
Project Start
1977-07-01
Project End
1986-04-30
Budget Start
1985-05-01
Budget End
1986-04-30
Support Year
15
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
Salzman, E W; Weinstein, M J; Reilly, D et al. (1993) Adventures in hemostasis. Desmopressin in cardiac surgery. Arch Surg 128:212-7
Penny, W F; Weinstein, M; Salzman, E W et al. (1991) Correlation of circulating von Willebrand factor levels with cardiovascular hemodynamics. Circulation 83:1630-6
Gerhart, T N; Yett, H S; Robertson, L K et al. (1991) Low-molecular-weight heparinoid compared with warfarin for prophylaxis of deep-vein thrombosis in patients who are operated on for fracture of the hip. A prospective, randomized trial. J Bone Joint Surg Am 73:494-502
Weinstein, M; Ware, J A; Troll, J et al. (1988) Changes in von Willebrand factor during cardiac surgery: effect of desmopressin acetate. Blood 71:1648-55
Salzman, E W; McManama, G P; Shapiro, A H et al. (1987) Effect of optimization of hemodynamics on fibrinolytic activity and antithrombotic efficacy of external pneumatic calf compression. Ann Surg 206:636-41
Salzman, E W; Weinstein, M J; Weintraub, R M et al. (1986) Treatment with desmopressin acetate to reduce blood loss after cardiac surgery. A double-blind randomized trial. N Engl J Med 314:1402-6
Bertele, V; Stemerman, M; Schafer, A et al. (1985) Refractoriness of platelets to prostaglandins after infusion in rabbits. J Lab Clin Med 106:551-61
Lewis, J; Sweeney, J; Baldini, L et al. (1985) Assessment of thromboresistance of intravenous cannulae by 125I-fibrinogen scanning. J Biomed Mater Res 19:99-113